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  • Your Good Partner in Biology Research

    MS4A1

    MS4A1基因编码CD20蛋白,该抗原为一种疏水性4次跨膜蛋白,分子量大约为35kDa。CD20也叫B淋巴细胞表面抗原B1、Bp35、白细胞表面抗原Leu-16等等。CD20只在B淋巴细胞上表达,参与调节B细胞活化和增殖,作为钙离子通道发挥作用。除在正常B细胞中表达外,CD20还在B细胞来源的淋巴瘤、白血病等的肿瘤细胞表达,以及涉及免疫疾病和炎症疾病的B细胞中表达,所以CD20抗原成为淋巴癌、白血病和某些自体免疫等疾病治疗的目标靶点。目前,针对这些疾病的CD20治疗主要有三种方式,包括抗CD20单克隆抗体、CAR-T和双特异性抗体。自1997年全球首款抗CD20单抗——罗氏的利妥昔单抗获批以来,全球已经批准多款抗CD20单抗。相关数据统计显示,目前有高达90多种针对CD20的生物制剂处于临床开发阶段。

    CUSABIO-哺乳包膜VLPs平台成功开发MS4A1全长膜蛋白(4次跨膜),展示了完整生物活性。

    Recombinant Human MS4A1-VLPs 活性蛋白实验验证数据

    High Specificity Validated by Western blot (WB)

    CSB-MP015007HU is detected by Mouse anti-6*His monoclonal antibody.

    Excellent Bioactivity Validated by Functional ELISA

    Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL.

    Correct Structure Validated
    by TEM

    The presence of VLP-like structures was confirmed by TEM.


    MS4A1 Antibodies

    MS4A1 for Mus musculus (Mouse)

    MS4A1 for Homo sapiens (Human)

    MS4A1 for H, M, R

    MS4A1 Proteins

    MS4A1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

    MS4A1 Proteins for Mus musculus (Mouse)

    MS4A1 Proteins for Homo sapiens (Human)

    MS4A1 ELISA Kit

    MS4A1 ELISA Kit for Homo sapiens (Human)



    1v1周青梅郑宣木天寥
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