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  • Your Good Partner in Biology Research

    KLRK1

    NKG2D蛋白(又称为CD314)由KLRK1基因编码,是一种人类天然杀伤细胞,在天然免疫中发挥着重要的作用。NKG2D作为一种活性受体,NKG2D可以在人类和小鼠的NK细胞、CD8+T细胞和其他免疫活性细胞中表达,但在CD4+T细胞中通常不表达。与其他NKG2受体不同,NKG2D拥有多种配体,包括人类MHC-I类链相关分子(MICA和MICB)和人类UL16结合蛋白(ULBPs,也称为人类RAET1)。NKG2D及其配体(NKG2D/NKG2DL)可以介导免疫细胞的肿瘤杀伤作用。NKX101是Nkarta所研发的第一个靶向NKG2D的“通用型”CAR-NK细胞疗法。用于治疗复发/难治性急性髓细胞白血病(AML)或高危骨髓增生异常综合征(MDS)。目前以NKG2D为靶点的在研药物/疗法主要集中在临床早期,作用机制以CAR-T/CAR-NK为主,适应症以血液瘤为主。除此之外CAR-NK疗法不需要以患者的自体免疫细胞作为来源、治疗成本更低等优势可能使它成为CAR-T疗法的一大竞争对手。

    Recombinant Human KLRK1 活性蛋白实验验证数据

    High Purity Validated by
    SDS-PAGE

    (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

    Excellent Bioactivity Validated by Functional ELISA

    Measured by its binding ability in a functional ELISA. Immobilized KLRK1 at 10 μg/ml can bind human Biotinylated ULBP1(CSB-MP887177HUj1-B), the EC50 is 4.254-7.295 ng/ml.

    Excellent Bioactivity Validated by LSPR Assay

    Human KLRK1 protein Fc tag (CSB-MP012474HU1) captured on COOH chip can bind Human ULBP1 protein Fc/myc tag (CSB-MP887177HU) with an affinity constant of 2.27 nM as detected by LSPR Assay.


    KLRK1 Antibodies

    KLRK1 for Homo sapiens (Human)

    KLRK1 Proteins

    KLRK1 Proteins for Homo sapiens (Human)

    KLRK1 Proteins for Mus musculus (Mouse)

    KLRK1 Proteins for Rattus norvegicus (Rat)

    KLRK1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

    KLRK1 Proteins for Pongo pygmaeus (Bornean orangutan)

    KLRK1 Proteins for Macaca mulatta (Rhesus macaque)

    KLRK1 Proteins for Sus scrofa (Pig)

    KLRK1 Proteins for Pan troglodytes (Chimpanzee)



    1v1周青梅郑宣木天寥
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