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  • Your Good Partner in Biology Research

    INSR

    Insulin receptor is a protein in humans that is encoded by INSR gene. Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways.

    INSR Antibodies

    INSR for Homo sapiens (Human)

    INSR Proteins

    INSR Proteins for Mus musculus (Mouse)

    INSR Proteins for Rattus norvegicus (Rat)

    INSR Proteins for Homo sapiens (Human)

    INSR Proteins for Xenopus laevis (African clawed frog)

    INSR Proteins for Macaca mulatta (Rhesus macaque)



    1v1周青梅郑宣木天寥
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