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  • Your Good Partner in Biology Research

    IKBKG

    NF-kappa-B essential modulator is a protein in humans that is encoded by IKBKG gene. Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.

    IKBKG Antibodies

    IKBKG for Homo sapiens (Human)

    IKBKG Proteins

    IKBKG Proteins for Mus musculus (Mouse)

    IKBKG Proteins for Rattus norvegicus (Rat)

    IKBKG Proteins for Bos taurus (Bovine)



    1v1周青梅郑宣木天寥
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