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  • Your Good Partner in Biology Research

    GHR

    生长激素-不仅仅促进长高

    生长激素结合蛋白(growth hormone binding protein,GHBP)是血液中生长激素(GH)的运输蛋白,代表着生长激素受体(GHR)的膜外部分,反应了组织GHR的浓度,对GH生物学作用的发挥起着重要的作用。GHBP作为生长素活性调节剂,进入血液循环的GH几乎都与高亲和力的GHBP结合在一起,刺激靶器官产生类胰岛素生长因子-1(insulin-like growth factor-1,IGF-1),GHBP再与IGF-1受体结合发挥作用,生长激素与IGF-1的这种关系也叫做生长激素/IGF-1轴。因此,GHBP是了解生长激素—胰岛素样生长因子(GH-IGF-1)轴变化的主要指标。研究发现血GHBP水平下降,可能与GH抵抗综合征有关,如肝硬化、肾功能不全、糖尿病、甲状腺功能减退症、营养不良症和重症急性疾病等等。

    Recombinant Human GHR 活性蛋白实验验证数据

    High Purity Validated
    by SDS-PAGE

    (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

    Excellent Bioactivity Validated by Functional ELISA

    Measured by its binding ability in a functional ELISA. Immobilized GH1 (CSB-MP009407HU) at 1 μg/ml can bind human GHR, the EC50 of human GHR protein is 24.96-33.39 ng/ml.

    Excellent Bioactivity Validated by LSPR Assay

    Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.


    GHR Antibodies

    GHR for Homo sapiens (Human)

    GHR Proteins

    GHR Proteins for Macaca mulatta (Rhesus macaque)

    GHR Proteins for Gallus gallus (Chicken)

    GHR Proteins for Homo sapiens (Human)

    GHR Proteins for Sus scrofa (Pig)

    GHR Proteins for Oryctolagus cuniculus (Rabbit)

    GHR Proteins for Mus musculus (Mouse)

    GHR Proteins for Bos taurus (Bovine)

    GHR Proteins for Bos indicus (Zebu)

    GHR Proteins for Rattus norvegicus (Rat)

    GHR Proteins for Saimiri boliviensis boliviensis (Bolivian squirrel monkey)

    GHR Proteins for Ailuropoda melanoleuca (Giant panda)

    GHR Proteins for Columba livia (Domestic pigeon)

    GHR Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

    GHR Proteins for Cavia porcellus (Guinea pig)

    GHR Proteins for Papio anubis (Olive baboon)

    GHR Proteins for Ovis aries (Sheep)



    1v1周青梅郑宣木天寥
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