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  • Your Good Partner in Biology Research

    ERBB3

    ERBB3(又称HER3,人表皮生长因子受体3)属于表皮生长因子受体家族(EGFR)。ERBB3在正常成人的胃肠道、生殖系统、皮肤、神经系统、泌尿道和内分泌系统中均有表达。事实上,ERBB3本身受到不同程度的调控,由2个泛素连接酶NEDD4和NRDP1调控其泛素化和蛋白体降解。ERBB3胞内区无内在的酪氨酸激酶活性不能自身磷酸化,但ERBB3能够与表皮生长因子受体家族其它成员,ERBB1(又称EGFR,HER1)、ERBB2/HER2和ERBB4/HER4形成异源性二聚体,激活下游通路,影响细胞的增殖分化。其中ERBB3/ERBB2复合物能够激活MAPK/ERK和PI3K/AKT在内的多种通路。大量研究表明, ERBB3过表达可见于乳腺癌、肺癌、结直肠癌、胃癌、头颈鳞癌、卵巢癌、黑色素瘤、前列腺癌和膀胱癌等。因此,通过靶向ERBB3,阻断ERBB3/ERBB2通路,正在为癌症治疗提供新途径。

    Recombinant Human ERBB3 活性蛋白实验验证数据

    High Purity Validated by SDS-PAGE

    (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

    Excellent Bioactivity Validated by Functional ELISA

    Measured by its binding ability in a functional ELISA. Immobilized NRG1(CSB-MP016077HU1(F6)) at 2 μg/ml can bind human ERBB3, the EC50 is 12.32-15.74 ng/ml.


    ERBB3 Antibodies

    ERBB3 for Homo sapiens (Human)

    ERBB3 Proteins

    ERBB3 Proteins for Homo sapiens (Human)

    ERBB3 Proteins for Rattus norvegicus (Rat)

    ERBB3 Proteins for Pongo abelii (Sumatran orangutan)

    ERBB3 Proteins for Mus musculus (Mouse)

    ERBB3 ELISA Kit

    ERBB3 ELISA Kit for Homo sapiens (Human)



    1v1周青梅郑宣木天寥
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