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  • Your Good Partner in Biology Research

    ERBB2

    人表皮生长因子受体2(HER2,也称ERBB2)是表皮生长因子受体家族中的一员。HER2具有酪氨酸激酶活性,在组织发育中起至关重要的作用,是胚胎发育所必需的。然而,HER2的过表达往往会引起正常生物学功能的紊乱。ERBB2尚没有已知的配体,必须与家族其他成员组成同源或异源二聚体,激活胞内的酪氨酸激酶活性,从而启动下游信号传导通路RAS-RAF-MEK-ERK以及PI3K-AKT-mTOR通路。越来越多的研究发现HER2与多种癌症相关,包括乳腺癌、胃癌、结肠癌、膀胱癌、卵巢癌、子宫内膜癌、肺癌等。其中,HER-2在乳腺癌和胃癌中的研究最为成熟。目前,HER2靶向药物治疗乳腺癌已取得显著的临床疗效,数据表明曲妥珠单抗,T-DM1,帕妥珠单抗在治疗过表达HER2的乳腺癌中,对患者预后有显著的改善作用。此外,针对胃癌、结直肠癌的研究也在进行中。

    Recombinant Human ERBB2 活性蛋白实验验证数据

    High Purity Validated by SDS-PAGE

    (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

    Excellent Bioactivity Validated by Functional ELISA

    Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.

    ERBB2 Antibodies

    ERBB2 for Homo sapiens (Human)

    ERBB2 for H, M, R

    ERBB2 for H

    ERBB2 Proteins

    ERBB2 Proteins for Mus musculus (Mouse)

    ERBB2 Proteins for Rattus norvegicus (Rat)

    ERBB2 Proteins for Homo sapiens (Human)

    ERBB2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

    ERBB2 Proteins for Mesocricetus auratus (Golden hamster)

    ERBB2 ELISA Kit

    ERBB2 ELISA Kit for Homo sapiens (Human)



    1v1周青梅郑宣木天寥
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