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  • Your Good Partner in Biology Research

    CREB3

    Cyclic AMP-responsive element-binding protein 3 is a protein in humans that is encoded by CREB3 gene. Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6).

    CREB3 Antibodies

    CREB3 for Homo sapiens (Human)

    CREB3 Proteins

    CREB3 Proteins for Homo sapiens (Human)

    CREB3 Proteins for Mus musculus (Mouse)

    CREB3 Proteins for Bos taurus (Bovine)



    1v1周青梅郑宣木天寥
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