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  • Your Good Partner in Biology Research

    COVID-19 Antibody Reagents

    SARS-CoV-2抗體

    新冠病毒引起的新冠肺炎疫情此起彼伏,對全球的醫療衛生系統和經濟帶來了巨大影響,同時也給新冠疫苗、治療藥物以及診斷帶來了新的挑戰。武漢華美生物一直密切關注新冠病毒的進化情況,目前已開發了大量高質量SARS-CoV-2相關抗體試劑,包括N抗體、S抗體、S RBD納米抗體、N抗體對和S RBD抗體對等。

    其中,N抗體與S抗體可用于新冠病毒致病性機理研究,可通過WB定性檢測新冠抗原;N抗體對和S RBD抗體對可用于新冠試劑盒的開發;另外,部分抗體驗證了中和試驗和主流突變株檢測,可作為質控品,應用于針對突變株的中和抗體篩選、重組蛋白疫苗研發、疫苗接種后血清中的中和抗體檢測等。

    華美特色

    • 抗體試劑類型多
    • 高特異性
    • 多種應用場景驗證
    • 多個主流突變株驗證

    部分應用場景及驗證數據

    ● WB定性抗原檢測

    Positive WB detected in: His tag-tagged SARS-CoV-2 N recombinant protein (CSB-EP3325GMY); SARS-CoV-2 N antibody at 1:1000 (CSB-RA33255A1GMY)

    Positive WB detected in: SARS-CoV-2 N recombinant protein (CSB-EP3325GMY) at 40ng, 20ng, 10ng; All lanes N antibody (CSB-MA33255A0m) at 1:1000

    ● 功能性ELISA驗證抗原-抗體結合活性

    Immobilized SARS-CoV-2-N (CSB-EP3325GMY) at 2 μg/mL can bind SARS-CoV-2-N (CSB-RA33255A0GMY) Antibody, the EC50 is 6.892 ng/mL.

    Immobilized SARS-CoV-2-S1-RBD (CSB-YP3324GMY1) at 2 μg/ml can bind SARS-CoV-2-S Antibody (CSB-MA33245A0m), the EC50 is 32.59 to 39.33 ng/mL.

    ● 用于膠體金(GICA)快速檢測

    In the GICA detection system, the background of antibody (CSB-RA33255A2GMY) is clean, the detection limit can be as low as 15.625ng/mL (1.09ng/0.07mL), and the sensitivity is very good.

    In the GICA detection system, the background of antibody (CSB-RA33245A0GMY) is clean, the detection limit can be as low as 13.94ng/mL (0.976ng/0.07mL), and the sensitivity is very good.

    ● 抗體對經S-ELISA驗證

    SARS-CoV-2 N Antibody Pair 1 (CSB-EAP33255A1) is a solid phase sandwich Enzyme Linked-Immuno-Sorbent Assay (Sandwich ELISA).

    SARS-CoV-2 Spike RBD Antibody Pair 1 (CSB-EAP33245) is a solid phase sandwich Enzyme Linked-Immuno-Sorbent Assay (Sandwich ELISA).

    ● 經中和試驗驗證中和抗體

    Binding signal of SARS-CoV-2-S1-RBD (CSB-YP3324GMY1) and ACE2 protein-HRP conjugate (CSB-MP866317HU) was inhibited by S Antibody (CSB-RA33245A1GMY) with the IC50 is 2.38 μg/mL

    Binding signal of SARS-CoV-2-S1-RBD (CSB-YP3324GMY1) and ACE2-HRP (CSB-YP3324GMY1) was inhibited by SARS-CoV-2 Spike RBD Nanobody (CSB-RA33245A2GMY) with the IC50 is 0.1074 μg/mL.

    ● 多個突變株識別驗證

    Protein Code Variants EC50 (ng/mL)
    CSB-EP3325GMY(M1) D3L, R203K, G204R, S235F 2. 562-3.421
    CSB-EP3325GMY(M2) T205I 29.34-40.67
    CSB-EP3325GMY(M3) P80R 63.78-113.6
    CSB-EP3325GMY(M4) P13L 2.825-4.124
    CSB-EP3325GMY(M5) D103Y 7.358-9.976
    CSB-EP3325GMY(M8) S202N 1.466-2.382
    CSB-EP3325GMY(M9) L230F 4.854-7.721
    CSB-EP3325GMY(M10) I292T 3.859-7.358
    CSB-EP3325GMY(M11) Q384H 2.785-4.100
    CSB-EP3325GMY(M12) R203K, G204R 4.664-8.256
    CSB-EP3325GMY(M13) R203M, D377Y 0.8488-1.385
    CSB-EP3325GMY(M14) D63G, R203M, D377Y 1.304-1.875

    The Binding Activity of N protein with N Recombinant Antibody. Activity: Measured by its binding ability in a functional ELISA. Immobilized N at 2 μg/mL can bind N Recombinant Antibody (CSB-RA33255A1GMY), the EC50 of N Recombinant Antibody.

    Protein Code Variants EC50 (ng/mL)
    CSB-MP3324GMY1(M8) E484K 371.0-487.5
    CSB-MP3324GMY1(M7) K417N 4.522-5.950
    CSB-MP3324GMY1(M6) N501Y 47.09-86.25
    Protein Code Variants EC50 (ng/mL)
    CSB-MP3324GMY1(M9) K417T 8.706-13.61
    CSB-MP3324GMY1(M10) K417N, E484K, N501Y 97.92-169.6
    CSB-MP3324GMY(M1) D614G 23.19-34.02

    The Binding Activity of S protein with S Recombinant Antibody. Activity: Measured by its binding ability in a functional ELISA. Immobilized S at 2 μg/mL can bind S Recombinant Antibody, the EC50 of S Recombinant Antibody (CSB-RA33245A1GMY).

    產品列表

    ● N antibody

    貨號 產品名稱 反應種屬 應用類型
    CSB-RA33255A1GMY N Antibody SARS-CoV-2 ELISA, WB, GICA
    CSB-RA33255A2GMY N Antibody SARS-CoV-2 ELISA
    CSB-MA33255A0m N Antibody GICA Mouse
    CSB-PA33254A0Rb N Antibody GICA Rabbit
    CSB-RA33255A0GMY N Antibody SARS-CoV-2 ELISA, GICA
    CSB-RA33255B1GMY N Antibody, HRP conjugated SARS-CoV-2 ELISA
    CSB-RA33255C1GMY N Antibody, FITC conjugated SARS-CoV-2 ELISA
    CSB-RA33255D1GMY N Antibody, Biotin conjugated SARS-CoV-2 ELISA
    CSB-MA33255A1m N Antibody GICA Mouse
    CSB-MA33255A2m N Antibody GICA Mouse
    CSB-PA33254B0Rb N Antibody, HRP conjugated SARS-CoV-2 ELISA
    CSB-PA33254C0Rb N Antibody, FITC conjugated SARS-CoV-2 ELISA
    CSB-PA33254D0Rb N Antibody, Biotin conjugated SARS-CoV-2 ELISA

    ● S antibody

    貨號 產品名稱 反應種屬 應用類型
    CSB-RA33245A1GMY S Antibody SARS-CoV-2 ELISA, GICA, Neutralising
    CSB-MA33245A2m S Monoclonal Antibody GICA Mouse
    CSB-PA33245YA01GMY S Antibody GICA Rabbit
    CSB-RA33245A0GMY S Antibody SARS-CoV-2 ELISA, GICA
    CSB-RA33245B1GMY S Antibody, HRP conjugated SARS-CoV-2 ELISA
    CSB-RA33245C1GMY S Antibody, FITC conjugated SARS-CoV-2 ELISA
    CSB-RA33245D1GMY S Antibody, Biotin conjugated SARS-CoV-2 ELISA
    CSB-MA33245A0m S Monoclonal Antibody GICA Mouse
    CSB-MA33245A1m S Monoclonal Antibody GICA Mouse
    CSB-PA33245YB01GMY S Antibody SARS-CoV-2 ELISA
    CSB-PA33245YC01GMY S Antibody SARS-CoV-2 ELISA
    CSB-PA33245YD01GMY S Antibody SARS-CoV-2 ELISA
    CSB-PA33245YA11GMY S Antibody GICA Rabbit
    CSB-PA33245YB11GMY S Antibody SARS-CoV-2 ELISA
    CSB-PA33245YC11GMY S Antibody SARS-CoV-2 ELISA
    CSB-PA33245YD11GMY S Antibody SARS-CoV-2 ELISA

    ● N Antibody Pair

    貨號 產品名稱 反應種屬 應用類型
    CSB-EAP33255A2 SARS-CoV-2 N Antibody Pair 2 SARS-CoV-2 S-ELISA
    CSB-EAP33255A1 SARS-CoV-2 N Antibody Pair 1 SARS-CoV-2 S-ELISA
    CSB-EAP33255A3 SARS-CoV-2 N Antibody Pair 3 SARS-CoV-2 S-ELISA
    CSB-EAP33255A4 SARS-CoV-2 N Antibody Pair 4 SARS-CoV-2 S-ELISA

    ● S RBD Nanobody Antibody

    貨號 產品名稱 反應種屬 應用類型
    CSB-RA33245A2GMY SARS-CoV-2 RBD Nanobody SARS-CoV-2 ELISA, GICA, Neutralising
    CSB-RA33245B2GMY SARS-CoV-2 RBD Nanobody, HRP conjugated SARS-CoV-2 ELISA
    CSB-RA33245C2GMY SARS-CoV-2 RBD Nanobody, FITC conjugated SARS-CoV-2 ELISA
    CSB-RA33245D2GMY SARS-CoV-2 RBD Nanobody, Biotin conjugated SARS-CoV-2 ELISA

    ● S RBD Antibody Pair

    貨號 產品名稱 反應種屬 應用類型
    CSB-EAP33245 SARS-CoV-2 Spike RBD Antibody Pair 1 SARS-CoV-2 S-ELISA


    1v1周青梅郑宣木天寥
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