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  • Your Good Partner in Biology Research

    Recombinant Rat Angiopoietin-2(Angpt2)

    • 货号:
      CSB-YP001707RA
    • 规格:
    • 来源:
      Yeast
    • 其他:
    • 货号:
      CSB-EP001707RA
    • 规格:
    • 来源:
      E.coli
    • 其他:
    • 货号:
      CSB-EP001707RA-B
    • 规格:
    • 来源:
      E.coli
    • 共轭:
      Avi-tag Biotinylated

      E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

    • 其他:
    • 货号:
      CSB-MP001707RA
    • 规格:
    • 来源:
      Mammalian cell
    • 其他:

    产品详情

    • 纯度:
      >85% (SDS-PAGE)
    • 基因名:
      Angpt2
    • Uniprot No.:
    • 别名:
      Angpt2; Agpt2Angiopoietin-2; ANG-2
    • 种属:
      Rattus norvegicus (Rat)
    • 蛋白长度:
      Full Length of Mature Protein
    • 表达区域:
      19-496
    • 氨基酸序列
      YN NFRKSVDSTG RRQYQVQNGP CSYTFLLPET DSCRSSSSPY MSNAVQRDAP LDYDDSVQRL QVLENILENN TQWLMKLENY IQDNMKKEMV EIQQNVVQNQ TAVMIEIGTS LLNQTAAQTR KLTDVEAQVL NQTTRLELQL LQHSISTNKL EKQILDQTSE INKLQDKNSF LEKKVLDMED KHSVQLQSMK EQKDQLQVLV SKQSSVIDEL EKKLVTATVN NSVLQKQQHD LMETVNSLLT MMSSPDYKSS VAVPKEEKTT FRDCAEIFKS GLTTSGIYTL TFPNSTEEVK AYCDMDMGGG GWTVIQHRED GSVDFQRTWK EYKEGFGSPL GEYWLGNEFV SQLTSGHRYV LKIQLKDWEG SEAHSLYEHF YLSGEESNYR IHLTGLTGTA GKISSISQPG SDFSTKDSDN DKCICKCSQM LTGGWWFDAC GPSNLNGQYY PQKQNTNKFN GIKWYYWKGS GYSLKATTMM IRPADF
    • 蛋白标签:
      The following tags are available.
      N-terminal His-tagged
      Tag-Free
      The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
    • 产品提供形式:
      Lyophilized powder
      Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
    • 复溶:
      We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
    • 储存条件:
      Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
    • 保质期:
      The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
      Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
    • 货期:
      Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
      Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
    • 注意事项:
      Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
    • Datasheet :
      Please contact us to get it.

    产品评价

    靶点详情

    • 功能:
      Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
    • 基因功能参考文献:
      1. Based on these findings, we propose that Cx43 was the Cx isoform involved in MEGJ-mediated VEC-dependent regulation of Ang-2, which induces iNOS protein expression and vascular hyporeactivity after hypoxia. PMID: 28637680
      2. H2S may play a protective role in infrarenal aortic clamping induced acute lung injury in rats by inhibiting inflammation and Ang2 release. PMID: 26781077
      3. Inhibition of angiopoietin-2 is an effective and safe treatment for liver fibrosis in CCl4 -treated rats, acting mainly through the induction of vessel normalization and the attenuation of hepatic inflammatory infiltrate. PMID: 24612347
      4. responsible for the vascular hyporeactivity at late hemorrhagic shock through the Tie2-Erk-iNOS pathway PMID: 22869617
      5. it is unlikely that induction of Ang-2 contributes to vascular dysfunction underlying functional impairment after spinal cord injury, but rather that it contributes to the beneficial pro-angiogenic and/or gliogenic processes PMID: 22020092
      6. Decreased angiopoietin1/Tie2 and increased angiopoietin2 expression may contribute to diabetes-induced vascular damage after stroke. PMID: 21515377
      7. Hyperoxia induced neovascularization and inhibited the expression of ang-2 in the retina. PMID: 19573435
      8. The expression of Ang-2 protein in serum was significantly positively correlated with the extent lung injury. PMID: 19900368
      9. Expression of angiopoietin-2 increased after stroke in all rat strains and was significantly enhanced in SHR stroke-prone compared with control strains PMID: 11822892
      10. These data suggest that Ang2 might modulate both angiogenesis and vascular regression in the rat brain and that capillary regression occurring during deadaptation involves activation of apoptosis. PMID: 12183511
      11. Expressed in rat brain during hypoxia and de-adaptation. PMID: 12580449
      12. we demonstrate that testicular vascular endothelial growth factor-A (VEGF-A), ang 1, ang 2, and the ang-receptor tie 2 are expressed in the testis PMID: 12773423
      13. Angiopoietin2 and Tie2, but not angiopoietin1 mRNA were increased with retinopathy of prematurity. PMID: 12937129
      14. Angiopoietin-1 but not angiopoietin-2 has a role in experimental glioma angiogenesis PMID: 15509526
      15. Following injury, Ang2 may play a role in BBB breakdown of perilesional vessels, and it may also be a factor in endothelial cell apoptosis that occurs at days 1 and 2 following the injury. PMID: 16056241
      16. Data demonstrate that vascular smooth muscle cells adjust angiopoietin-2 expression through multiple mechanisms, including changes in transcription as well as posttranscriptional mRNA destabilization. PMID: 16176970
      17. Up-regulation of Ang-2, a proangiogenic factor, and the down-regulation of PEDF, an antiangiogenic factor, is indicative of an imbalance between pro- and antiangiogenic factors in the hypoxic retina that may favor neovascularization. PMID: 17943991
      18. glomerular expression of ANG-1 and ANG-2 is differentially regulated and may contribute to healing and endothelial cell stabilization in experimental glomerulonephritis PMID: 18272601
      19. Abnormal expression and reciprocal egulation of Angpt2 may play important roles in the development of chronic allograft nephropathy in rat renal allografts. PMID: 18929864
      20. Ang2-derived tumor vessels lead to an inadequate oxygenation of the tumor tissue, leading to impairment in tumor growth PMID: 19168695

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    • 亚细胞定位:
      Secreted.
    • 数据库链接:


    1v1周青梅郑宣木天寥
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