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    Recombinant Human Insulin-like growth factor-binding protein 7(IGFBP7)

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    • 共轭:
      Avi-tag Biotinylated

      E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

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    • 来源:
      Mammalian cell
    • 其他:


    • 纯度:
      >85% (SDS-PAGE)
    • 基因名:
    • Uniprot No.:
    • 别名:
      AGM; Angiomodulin; FSTL2; IBP-7; IBP7; IBP7_HUMAN; IGF binding protein 7; IGF-binding protein 7; IGFBP rP1; IGFBP-7; IGFBP-rP1; IGFBP7; IGFBPRP1; Insulin like growth factor binding protein 7; Insulin-like growth factor-binding protein 7; MAC25; MAC25 protein; PGI2 stimulating factor; PGI2-stimulating factor; Prostacyclin stimulating factor; Prostacyclin-stimulating factor; PSF; RAMSVPS; TAF; Tumor-derived adhesion factor
    • 种属:
      Homo sapiens (Human)
    • 蛋白长度:
      Full Length of Mature Protein
    • 表达区域:
    • 氨基酸序列
    • 蛋白标签:
      The following tags are available.
      N-terminal His-tagged
      The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
    • 产品提供形式:
      Lyophilized powder
      Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
    • 复溶:
      We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
    • 储存条件:
      Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
    • 保质期:
      The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
      Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
    • 货期:
      Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
      Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
    • 注意事项:
      Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
    • Datasheet :
      Please contact us to get it.



    • 功能:
      Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
    • 基因功能参考文献:
      1. Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum. PMID: 29563502
      2. IGFBP7 upregulation promotes osteogenic differentiation of mesenchymal stem cells via the Wnt/beta-catenin signaling. PMID: 29242275
      3. Low IGFBP7 expression is associated with Gastric Cancer. PMID: 29580038
      4. Reduced RNA editing of IGFBP7 gene is associated with psoriasis. PMID: 29592874
      5. Urine levels of IGFBP7 (and TIMP2) are predictive for acute kidney injury following cardiac surgical procedures. PMID: 28803769
      6. IGFBPrP1 transfection inhibited cell growth, and induced G1 phase arrest and cellular senescence in HEC1A cells while gene silencing presented the adverse functional changes. PMID: 29067463
      7. Serum IGFBP7 levels were raised during acute exacerbation in COPD patients. PMID: 28684903
      8. biomarker for acute kidney injury PMID: 27174659
      9. epithelial cells and leukocytes from the urinary sediment. CONCLUSION: The gene expression pattern of IGFBP7 and TIMP-2 from urinary sediment, which contains desquamated renal tubular epithelial cells, did not correlate with [IGFBP7]x[TIMP-2] protein, indicating that IGFBP7 and TIMP-2 measured in the NephroCheck(R) test originated predominantly from intact but stressed cells of the kidney itself PMID: 29145491
      10. In patients with heart failure with preserved ejection fraction, IGFBP7 may be a novel biomarker of diastolic function and exercise capacity. PMID: 27744089
      11. High IGFBP7 expression is associated with acute kidney injury. PMID: 27342580
      12. NEAT1-associated paraspeckle proteins P54nrb and PSF have been reported as positive regulators of c-Myc translation through interaction with c-Myc IRES PMID: 28288210
      13. Urine [TIMP-2]*[IGFBP7] is a promising candidate for early detection of AKI, especially in ruling-out AKI PMID: 28107490
      14. Meta-analysis indicated that urinary [TIMP-2].[IGFBP7] may be a reliable biomarker for the early detection of acute kidney injury in adults. PMID: 28682920
      15. TIMP-2 is both expressed and secreted preferentially by cells of distal tubule origin, while IGFBP7 is equally expressed across tubule cell types yet preferentially secreted by cells of proximal tubule origin. In human kidney tissue, strong staining of IGFBP7 was seen in the luminal brush-border region of a subset of proximal tubule cells, and TIMP-2 stained intracellularly in distal tubules. PMID: 28003188
      16. loss of IGFBP7 and upregulation of IGF1 activates the FGF4-FGFR1-ETS2 pathway in Tumor-associated endothelial cells (TECs) and converts naive tumor cells to chemoresistant tumor stem-like cells (TSCs), thereby facilitating their invasiveness and progression. PMID: 27989801
      17. Data report that IGFBP7 is a novel target gene of ADAR2 in esophageal squamous cell carcinoma where its RNA is edited and protein stabilized by ADAR2. PMID: 28035363
      18. quantitative urine test is available to assess the risk of developing AKI by measuring the concentrations of two protein biomarkers, TIMP-2 and IGFBP-7 PMID: 26797672
      19. Insulin-like growth factor binding protein 7 (IGFBP7) was proven to be associated with metastatic clinicopathological features and high lymphatic vascular density PMID: 26706909
      20. This process not only provides a remarkable high expression at ~50mg/L and pure glycosylated mammalian rhIGFBP7, also highlights that transient gene expression technology is practical to be used for production PMID: 26474694
      21. data suggest that TGF-beta1 enhances IGFBP7 via Smad2/4 pathways, and that IGFBP7 might be involved in the TGF-beta1-induced tubular injury in DN. PMID: 26974954
      22. This study shows that urinary [TIMP-2]*[IGFBP7] has a good diagnostic performance in predicting adverse outcomes in neonatal and pediatric AKI of heterogeneous etiology. PMID: 26606754
      23. low expression in breast cancer tissue PMID: 26387651
      24. serum IGFBP7 levels are associated with IR and MetS, providing new insight into the mechanism of IR and Mets. IGFBP7 may be a potential interventional target for IR and Mets. PMID: 25984973
      25. IGFBP-7 can alter EMT relative marker genes and suppress cell invasion in A253 cell through AKT/GSK3beta/beta-catenin signaling. PMID: 25880247
      26. IGFBP7 down-regulation is associated with poor prognosis in glioma, and this molecule may represent both a prognostic marker and a potential therapeutic target. PMID: 24743871
      27. Our data indicate that IGFBP7 expression is a marker for a specific methylation pattern in myeloma PMID: 25887188
      28. The low levels of IGFBP7 in high-grade serous ovarian carcinoma are associated with survival rate. PMID: 25886299
      29. Overexpression of IGFBP7 was associated with tumour progression and poor survival in gastric cancer. IGFBP7 may play a role in tumour progression in gastric cancer. PMID: 26043748
      30. we demonstrated that IGFBP-rP1 suppresses EMT and tumor metastasis by repressing TGF-b-mediated EMT through the Smad signaling cascade. PMID: 25789970
      31. IGFBP7 in urine was identified as a reliable marker of cell cycle arrest induction in acute kidney injury. PMID: 23388612
      32. The decline in urinary TIMP-2 and IGFBP7 values was the strongest predictor for renal recovery following cardiac surgery. PMID: 24675717
      33. in contrast to its tumor-suppressor function in epithelial cells, IGFPB7 can promote anchorage-independent growth in malignant mesenchymal cells and in epithelial cells with an EMT phenotype when IGFBP7 is expressed by the tumor cells PMID: 24632618
      34. These results suggest that AGM cooperates with VEGF to induce the aberrant functions of cancer vasculature as a ligand of integrin alpha5beta3. PMID: 24737780
      35. AML patients with high IGFBP7 expression have a better outcome than patients with low IGFBP7 expression, indicating a positive role for IGFBP7 in treatment and outcome of AML. PMID: 24967962
      36. Data indicate that insulin-like growth factor binding protein 7 (IGFBP7) was downregulated in gastric cancer, and its low expression was potentially correlated with increased cell proliferation and could be used to predicate poor prognosis in patients. PMID: 24894674
      37. as urinary marker, discriminated between early and late/non-recovery patients and patients with and without acute kidney injury PMID: 24067438
      38. IGFBP-rP1 contributes to the development of liver fibrosis and may be a novel molecule involved in the progression of hepatic fibrogenesis. PMID: 24373620
      39. High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-beta and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner. PMID: 24427302
      40. These data suggest that IGFBP7 is a critical regulator of memory consolidation and might be used as a biomarker for AD. PMID: 24075854
      41. Methylation of the IGFBP7 promoter was associated with silencing of gene expression and was frequent in Barrett's oesophagus and oesophageal adenocarcinoma PMID: 24357797
      42. Perfomed proteomic analysis on a transgenic mouse model of severe cardiac hypertrophy; compared data to dataset of heart failure found MYH7, IGFBP7, ANXA2, and DESM to be biomarker candidates for heart failure. PMID: 23713052
      43. Report A-to-I editing in the coding sequence of IGFBP7 in cancerous human keratinocytes. PMID: 23543219
      44. hypomethylation of LINE-1 and hypermethylation of SLIT2, MAL and IGFBP7 were frequently detected in NSCLCs and associated with various clinical features. PMID: 23381221
      45. Results indicate that restoration of IGFBP-rP1 to PC-3 cells increases both their radiosensitivity and chemosensitivity. PMID: 23600329
      46. Low expression of IGFBP7 is associated with pancreatic ductal adenocarcinoma. PMID: 22622471
      47. Hyperinsulinemia and high IGFBP-rP1 levels confer altered risks for endometrial carcinoma. PMID: 22544761
      48. Results demonstrate that CpG methylation of IGFBP7 may represent a novel biomarker of prostate cancer and pre-invasive neoplasms PMID: 22906661
      49. editing of IGFBP7 transcripts impacts the protein's susceptibility to proteolytic cleavage, thus providing a means for a cell to modulate its functionality through A-to-I RNA editing PMID: 22750143
      50. Transfection of IGFBP-rP1 or addition of condition medium (CM) from IGFBP-rP1-transfected cells in MCF-7 cells caused induction of a variety of senescent phenotypes. PMID: 22392074



    • 相关疾病:
      Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS)
    • 亚细胞定位:
    • 数据库链接:

      HGNC: 5476

      OMIM: 602867

      KEGG: hsa:3490

      STRING: 9606.ENSP00000295666

      UniGene: Hs.479808

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