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    Recombinant Human Apolipoprotein O(APOO) ,partial

    • 货号:
      CSB-YP001948HU1
    • 规格:
    • 来源:
      Yeast
    • 其他:
    • 货号:
      CSB-EP001948HU1
    • 规格:
    • 来源:
      E.coli
    • 其他:
    • 货号:
      CSB-EP001948HU1-B
    • 规格:
    • 来源:
      E.coli
    • 共轭:
      Avi-tag Biotinylated

      E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

    • 其他:
    • 货号:
      CSB-BP001948HU1
    • 规格:
    • 来源:
      Baculovirus
    • 其他:
    • 货号:
      CSB-MP001948HU1
    • 规格:
    • 来源:
      Mammalian cell
    • 其他:

    产品详情

    • 纯度:
      >85% (SDS-PAGE)
    • 基因名:
      APOO
    • Uniprot No.:
    • 别名:
      APOO; FAM121B; MIC23; MIC26; My025; UNQ1866/PRO4302; MICOS complex subunit MIC26; Apolipoprotein O; MICOS complex subunit MIC23; Protein FAM121B
    • 种属:
      Homo sapiens (Human)
    • 蛋白长度:
      Partial
    • 蛋白标签:
      The following tags are available.
      N-terminal His-tagged
      Tag-Free
      The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
    • 产品提供形式:
      Lyophilized powder
      Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
    • 复溶:
      We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
    • 储存条件:
      Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
    • 保质期:
      The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
      Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
    • 货期:
      Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
      Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
    • 注意事项:
      Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
    • Datasheet :
      Please contact us to get it.

    产品评价

    靶点详情

    • 功能:
      Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function. Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts. Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL.
    • 基因功能参考文献:
      1. The human apolipoprotein MIC26 is a bona fide subunit of the MICOS complex. PMID: 25764979
      2. It is likely that apoO participates in fatty acid metabolism and the inflammatory response in HepG2 cells. PMID: 24341743
      3. APOO represents a link between impaired mitochondrial function and cardiomyopathy onset, and targeting APOO-dependent metabolic remodeling has potential as a strategy to adjust heart metabolism and protect the myocardium from impaired contractility. PMID: 24743151
      4. relationships between plasma apoO levels and high-sensitive C-reactive protein (hs-CRP) levels, as well as other lipid parameters in healthy subjects and patients with established acute coronary syndrome PMID: 22693255
      5. apolipoprotein O is the first chondroitin sulfate chain containing apolipoprotein PMID: 16956892

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    • 亚细胞定位:
      Mitochondrion inner membrane; Single-pass membrane protein. Secreted. Mitochondrion. Golgi apparatus membrane. Endoplasmic reticulum membrane.
    • 蛋白家族:
      Apolipoprotein O/MICOS complex subunit Mic27 family
    • 组织特异性:
      Expressed in all tissues examined. Up-regulated in diabetic heart.
    • 数据库链接:

      HGNC: 28727

      OMIM: 300753

      KEGG: hsa:79135

      STRING: 9606.ENSP00000368528

      UniGene: Hs.495851



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