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    Recombinant Human ADP/ATP translocase 3(SLC25A6),partial

    • 貨號:
      CSB-EP021520HU1
    • 規格:
    • 圖片:
      • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • 其他:

    產品詳情

    • 純度:
      Greater than 85% as determined by SDS-PAGE.
    • 基因名:
      SLC25A6
    • Uniprot No.:
    • 種屬:
      Homo sapiens (Human)
    • 蛋白長度:
      Partial
    • 來源:
      E.coli
    • 分子量:
      20.2 kDa
    • 表達區域:
      232-272aa
    • 氨基酸序列
      DTVRRRMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFK
      Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
    • 蛋白標簽:
      N-terminal 6xHis-KSI-tagged
    • 產品提供形式:
      Liquid or Lyophilized powder
      Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
    • 緩沖液:
      If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
    • 復溶:
      We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
    • 儲存條件:
      Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
    • 保質期:
      The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
      Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
    • 貨期:
      Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    • 注意事項:
      Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
    • Datasheet & COA:
      Please contact us to get it.

    產品評價

    靶點詳情

    • 功能:
      ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it.
    • 基因功能參考文獻:
      1. Human ANT3 expression is directly downregulated by overexpression of hcmv-miR-UL36-5p. PMID: 26212361
      2. The dynamics of the molecular interactions between the C-terminal region of PB1-F2 protein and VDAC1 and ANT3 were expounded by employing an in silico approach. PMID: 19669810
      3. Of three ANT isoforms expressed in yeast, ANC3 is the most efficient to restore yeast growth on a nonfermentable carbon source of a yeast mutant strain lacking its three endogenous ANC. PMID: 12450408
      4. Results demonstrate that induction of adenine nucleotide translocase 3 by interleukin-4 and interferon-gamma proceeds via pathways involving STAT6 and STAT1, respectively. PMID: 14746803
      5. ANT3 overexpression induces apoptosis in cultured cells. PMID: 15063741
      6. ANT3 has a potential role in T-helper cell survival and immune cell homeostasis. PMID: 16930576
      7. involvement of ANT in cell death is cell type- and stimulus-dependent PMID: 17855512
      8. These data suggest that the down-regulation of ANT3 levels upon stimulation with CPT may be involved in the molecular mechanism underlying acquired resistance to camptothecin. PMID: 19111545

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    • 亞細胞定位:
      Mitochondrion inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
    • 蛋白家族:
      Mitochondrial carrier (TC 2.A.29) family
    • 組織特異性:
      Expressed in erythrocytes (at protein level).
    • 數據庫鏈接:

      HGNC: 10992

      OMIM: 300151

      KEGG: hsa:293

      STRING: 9606.ENSP00000370808

      UniGene: Hs.350927



    1v1周青梅郑宣木天寥
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