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  • Your Good Partner in Biology Research

    Recombinant Bovine Angiopoietin-2(ANGPT2)

    • 货号:
      CSB-YP001707BO
    • 规格:
    • 来源:
      Yeast
    • 其他:
    • 货号:
      CSB-EP001707BO
    • 规格:
    • 来源:
      E.coli
    • 其他:
    • 货号:
      CSB-EP001707BO-B
    • 规格:
    • 来源:
      E.coli
    • 共轭:
      Avi-tag Biotinylated

      E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

    • 其他:
    • 货号:
      CSB-BP001707BO
    • 规格:
    • 来源:
      Baculovirus
    • 其他:
    • 货号:
      CSB-MP001707BO
    • 规格:
    • 来源:
      Mammalian cell
    • 其他:

    产品详情

    • 纯度:
      >85% (SDS-PAGE)
    • 基因名:
      ANGPT2
    • Uniprot No.:
    • 别名:
      ANGPT2; ANG2Angiopoietin-2; ANG-2
    • 种属:
      Bos taurus (Bovine)
    • 蛋白长度:
      Full Length of Mature Protein
    • 表达区域:
      19-496
    • 氨基酸序列
      HS GSRKGMDIAA GKKQYQVQHG ACSYTFLLPE TDHCRSPSSA YVPNAVQRDA PLDYDDSVQR LQVLENIMEN NTQWLMKLEN YIQDNMKKEM VEIQQNAVQN QTAVMIEIGT NLLNQTAEQT RKLTDVEAQV LNQTTRLELQ LLEHSLSTNK LEKQILDQTS EISKLQDKNS FLEKKVLDME DKHIVQLRSI KEEKDQLQVL VSKQNSIIEE LEKQLVTATV NNSVLQKQQH DLMETVNNLL TLMSTSNPSY SLLAKDEQII FRDCGEAFKS GLTTSGVYTL TFPNSTEEIK AYCDMETGGG GWTVIQRRED GSVDFQRTWK EYKVGFGNPS GEHWLGNEFV SQVTGQKRYV LKIHLRDWEG NEAYSLYDHF YLSNEELNYR IHLKGLTGTA GKISSISQPG NDFSTKDADN DKCICKCSQM LTGGWWFDAC GPSNLNGMYY PQRQNTNKFN GIKWYYWKGS GYSLKATTMM IRPADF
    • 蛋白标签:
      The following tags are available.
      N-terminal His-tagged
      Tag-Free
      The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
    • 产品提供形式:
      Lyophilized powder
      Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
    • 复溶:
      We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
    • 储存条件:
      Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
    • 保质期:
      The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
      Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
    • 货期:
      Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
      Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
    • 注意事项:
      Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
    • Datasheet :
      Please contact us to get it.

    产品评价

    靶点详情

    • 功能:
      Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
    • 基因功能参考文献:
      1. polymorphisms significantly associated with milk somatic cell score PMID: 23726425
      2. Hypoxic regulation of Ang-2 is HIF-dependent and demonstrate that HIF-1alpha binds in human microvascular endothelial cells (HMVEC) to an evolutionary conserved Hypoxia-Responsive Element (HRE) located in the first intron of the Ang-2 gene. PMID: 18720385
      3. The mRNA expression for ANPT-2 was drastically decreased in the follicles with E(2)>5 ng/ml. PMID: 15329480
      4. Activation of the PI3-K/Akt pathway downregulates Angiopoietin-2 reveals an additional mechanism through which the PTEN/PI3-K/Akt pathway could affect the angiogenic process. PMID: 16447257
      5. Ang2 produced by oscillatory shear stress in endothelial cells plays a critical role in migration/tubule formation. May have role in diseases with disturbed flow/angiogenesis. PMID: 17673702
      6. In mature and late regressing corpus luteum, high scores of Ang-2-immunopositive endothelial and smooth muscle cells were found. PMID: 18541291

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    • 亚细胞定位:
      Secreted.
    • 数据库链接:

      KEGG: bta:282141

      STRING: 9913.ENSBTAP00000014656

      UniGene: Bt.137



    1v1周青梅郑宣木天寥
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