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  • Your Good Partner in Biology Research

    MPO Antibody

    • 货号:
    • 规格:
    • 图片:
      • IHC image of CSB-RA617176A0HU diluted at 1:100 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
    • 其他:


    • 产品描述:

      MPO is largely produced by neutrophils in order to defend against infections. MPO is involved in the formation and maintenance of an alkaline environment in freshly formed phagosomes, which is ideal for combating bacteria. MPO generates powerful oxidants, such as hypochlorous acid (HOCl), which kill bacteria and other invading pathogens. On the other hand, MPO plays a role in the development of a number of chronic inflammatory disorders, including atherosclerosis, neurological diseases, arthritis, and cancer.

      The recombinant MPO antibody was produced by cloning antibody genes into an expression vectors, which were subsequently introduced into mammalian cells to provide animal-free antibody production. This MPO antibody has been validated in ELISA, IHC. It has the features of improved affinity, stability, and consistency between different batches.

    • Uniprot No.:
    • 基因名:
    • 别名:
      Myeloperoxidase (MPO) (EC [Cleaved into: Myeloperoxidase, 89 kDa myeloperoxidase, 84 kDa myeloperoxidase, Myeloperoxidase light chain, Myeloperoxidase heavy chain], MPO
    • 反应种属:
    • 免疫原:
      A synthesized peptide derived from human Myeloperoxidase
    • 免疫原种属:
      Homo sapiens (Human)
    • 标记方式:
    • 克隆类型:
    • 抗体亚型:
      Rabbit IgG
    • 纯化方式:
    • 克隆号:
    • 浓度:
      It differs from different batches. Please contact us to confirm it.
    • 保存缓冲液:
      Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
    • 产品提供形式:
    • 应用范围:
      ELISA, IHC
    • 推荐稀释比:
      Application Recommended Dilution
      IHC 1:50-1:200
    • Protocols:
    • 储存条件:
      Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
    • 货期:
      Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.



    • 功能:
      Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
    • 基因功能参考文献:
      1. findings indicate that cyanide is a substrate for MPO and suggest an additional pathway for in vivo cyanate formation and protein carbamylation that involves MPO either directly or via its reaction products hypochlorous acid or chloramines. They also suggest that chronic cyanide exposure could promote the accumulation of carbamylated proteins in atherosclerotic plaques. PMID: 29496995
      2. These results indicate significant increases of MPO-immunoreactive cells in brain regions affected by neurodegeneration in Parkinson's disease and Alzheimer's Disease. PMID: 28466093
      3. Evidence has been presented for FN modification by inflammatory oxidants, and particularly myeloperoxidase (MPO)-derived species including hypochlorous acid (HOCl). Studies using primary human coronary artery smooth muscle cells show that exposure to HOCl-modified FN, results in decreased adherence, increased proliferation and altered expression of genes involved in extracellular matrix synthesis and remodelling. PMID: 30237127
      4. MPO -463G > A was not associated with chronic kidney disease (CKD) susceptibility in recessive model and homozygote comparison. Owing to insufficient data, the association between MPO -463G > A and CKD cannot be fully confirmed. [meta-analysis] PMID: 30278820
      5. data suggest that the decomposition of dimeric MPO into monomers can serve as a regulatory mechanism that controls MPO-dependent activation of neutrophils and reduces the proinflammatory effects of MPO. PMID: 29585927
      6. High MPO expression is associated with cardiometabolic risk factors, and distal sensorimotor polyneuropathy. PMID: 29577557
      7. Our results suggest that the presence of MPO polymorphism, -463 G>A in patients might offer them protection against cervical cancer. PMID: 29937309
      8. Results found that myeloperoxidase genes is up-regulated in both overweight and obese subjects and associated with BMI and markers of cardiovascular disease. PMID: 30056589
      9. Myeloperoxidase -463 G/A polymorphism is associated with lung cancer risk. PMID: 29970677
      10. MPO gene SNP (rs2107545) was associated with type 2 diabetes mellitus susceptibility in Chinese Han population. PMID: 29383971
      11. Myeloperoxidase serum level in stable coronary disease is predicitve of the risk of acute coronary syndrome. PMID: 29618370
      12. According to results, MPO G+ genotype and AG genotype were significantly increased in endometrial carcinoma patients as compared to controls. PMID: 29631687
      13. The level of myeloperoxidase in plasma of patients with acute myocardial infarction depends on the functional state of neutrophils. PMID: 29975476
      14. Glycosylation critically determines the enzymatic activity of MPO. Deglycosylation decreased oxidation activity of MPO and its binding with ceruloplasmin and decreased the microbicidal effect of MPO. Deglycosylated MPO presented less antigenicity to MPO-ANCA. PMID: 27643667
      15. Maternal myeloperoxidase activity was similar in both neural tube defect-affected pregnancies and healthy controls. PMID: 28397206
      16. Data show that pro-myeloperoxidase (pro-MPO) was more frequently detected in plasma from patients with myocardial infarction compared to plasma from control donors. PMID: 29590135
      17. Increased MPO indexed to HDL particle concentration (MPO/HDLp) at baseline is associated with increased risk of incident cardiovascular disease events. PMID: 28645072
      18. Evidence was sufficient to show the association between MPO-463G > A polymorphism and cancer risk.[meta-analysis] PMID: 28764808
      19. Aberrant glycosylated MPO exposed neo-epitopes and was recognized by half of the patients with anti-GBM disease. Their antibodies possessed pathogenic characteristics and may be associated with kidney injury. PMID: 28187981
      20. Data suggest that increased serum anti-MPO antibody levels are associated with retinal photoreceptor ellipsoid zone disruption and decreased visual acuity in diabetic retinopathy in patients with type 2 diabetes. This study was conducted in India. PMID: 28279572
      21. MPO concentrations showed positive correlations with sCD40L, ADMA, and sICAM-1 levels in overweight patients with newly diagnosed untreated hyperlipidaemia. PMID: 28602123
      22. This study revealed that epistatic interaction among the ALOX5, ALOX5AP and MPO genes played a significant role in vulnerability to ischemic stroke. PMID: 29041000
      23. Osteopontin, neopterin, and myeloperoxidase were independently associated with the risk of recurrent stroke and improved risk classification when added to a clinical risk algorithm PMID: 29114094
      24. peroxidase enzymes, like MPO and EPO, may play a fundamental role in inhibiting RANKL-induced osteoclast differentiation at inflammatory sites of bone fracture and injury. PMID: 27836774
      25. MPO complexed with HLA class II molecules is involved in the pathogenesis of MPA as a target for MPO-ANCA. PMID: 28575531
      26. PIC1 inhibits the peroxidase activity of myeloperoxidase in Cystic fibrosis sputum likely via an antioxidant mechanism. PMID: 28135312
      27. In absence of CALR, immature MPO protein precursors are degraded in the proteasome. PMID: 27013444
      28. Meta-analysis suggested an association between the MPO 463G/A polymorphism and the risk of coronary artery disease, but there is no significant association between the MPO 129G/A gene polymorphism and coronary artery disease risk. PMID: 28682877
      29. Both MPO and EPO are causatively involved in breast cancer progression and identified as potential therapeutic targets whereby specific novel inhibitors may reduce tumor growth and limit the occurrence of metastasis. PMID: 28260049
      30. Although IgA anti-MPO antibodies are detectable in some patients with eosinophilic granulomatosis with polyangiitis and may be detectable more frequently during active disease, their presence seems unlikely to provide information beyond what is obtained from conventional IgG anti-MPO. PMID: 28281453
      31. Clinical manifestations varied ANCA-associated vasculitis categories, and neither MPO-ANCA nor PR3-ANCA significantly affected relapse of AAV. PMID: 28339364
      32. MPO levels were higher in those patients infected with H. pylori irrespective of the virulence factors than those uninfected patients. PMID: 27048452
      33. The present study determined that ARE, CLP, CAT, and MPO levels are different between the pediatric patients with sepsis and healthy controls. ARE level can be a potent biomarker for sepsis in critical patients in intensive care units. PMID: 28167245
      34. Studies of the mutants C158A, C319A, and C158A/C319A demonstrated significant differences from the wild-type protein, including diminished enzymatic activity and prevention of export to the Golgi due to prolonged association with the chaperone calnexin. These structural and functional findings provide novel insights into MPO biosynthesis and processing. PMID: 28348079
      35. Consistent with these in vitro data, in diabetic rat aortas, both MPO expresion and NADPH oxidase activity were increased while the endothelial function was simultaneously impaired. The results suggested that vascular-bound MPO could amplify high glucose-induced vascular injury in diabetes. MPO-NADPH oxidase-HOCl may represent an important pathogenic pathway in diabetic vascular diseases. PMID: 28131839
      36. Patients with active disease demonstrated hypomethylation of myeloperoxidase and proteinase 3 and increased expression of the autoantigens; in remission, DNA methylation generally increased PMID: 27821628
      37. Myeloperoxidase-oxidized high density lipoprotein impairs atherosclerotic plaque stability by inhibiting smooth muscle cell migration. PMID: 28069011
      38. The roles of myeloperoxidase in coronary artery disease [review] PMID: 27884085
      39. Study shows that MPO and PRTN3 in neutrophils of Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) patients with active disease have a distinct pattern of histone modifications, which implicates epigenetic mechanisms in regulating expression of autoantigen genes and suggests that the epigenome may be involved in AAV pathogenesis. PMID: 27752292
      40. Data suggest that the system of MPO/hydrogen peroxide/chloride ions exhibits activity able to oxidize dibromoacetonitrile, a by-product of water treatment/disinfection and potential carcinogen, to cyanide, a known poison. PMID: 25614581
      41. Compared with the commercial human MPO ELISA assay, the MPO-ISA can be used to detect the natural human MPO protein, but not recombinant MPO polypeptides. The generated mAbs and MPO-ISA test may be useful tools to assess risk for inflammation and cardiac events PMID: 26978734
      42. The MPO gene -463G/A polymorphism is associated with Coronary Artery Disease risk, especially within the Chinese population. PMID: 28328864
      43. Study demonstrated that the MPO -463G>A SNP may protect from cervical squamous cell carcinoma in women from Polish Caucasian populations. PMID: 27197583
      44. The collected data showed a correlation between the occurrence of superimposed thrombosis in respiratory infection patients, and the intensity of the inflammatory process, reflected by the increased MPO activity, and the dynamics of LpPLA2 and VEGF. PMID: 27928450
      45. results suggest that the acute inflammatory response induced by thermal injury involves activation of neutrophils and is accompanied by MPO release into the plasma. MPO-mediated modification of serum albumin induces its capacity to prime neutrophils and thus to enhance further inflammatory reaction. PMID: 27797335
      46. The difference in MPO between women with abnormal and normal menstrual cycles and the upregulation of MPO before ovulation suggest that neutrophils and MPO are closely related to ovulation. PMID: 28013526
      47. The results suggest that G allele of Myeloperoxidase -463G>A polymorphism is a potential genetic marker for Kawasaki disease risk in Taiwanese children. PMID: 26066543
      48. Genetic polymorphisms in eNOS, catalase and myeloperoxidase and their significance in a cohort of Turkish prostate cancer patients. PMID: 27706591
      49. ANCA affinity was associated with the in vivo formation of neutrophil extracellular traps, which might be involved in the pathophysiology of patients with MPO-ANCA-associated microscopic polyangiitis. PMID: 26833773
      50. Study demonstrated the possibility of biodegradation of fullerene molecule using the human neutrophil enzyme myeloperoxidase, which leads to the formation of non-aromatic compounds and to the loss of the fullerene molecule topology PMID: 28058679



    • 相关疾病:
      Myeloperoxidase deficiency (MPOD)
    • 亚细胞定位:
    • 蛋白家族:
      Peroxidase family, XPO subfamily
    • 数据库链接:

      HGNC: 7218

      OMIM: 254600

      KEGG: hsa:4353

      STRING: 9606.ENSP00000225275

      UniGene: Hs.458272

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