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    MME Antibody

    Datasheet
    • 貨號:
      CSB-RA940661A0HU
    • 規格:
      ¥2200
    • 圖片:
      • Western Blot
        Positive WB detected in: U251 whole cell lysate
        All lanes: MME antibody at 1:1500
        Secondary
        Goat polyclonal to rabbit IgG at 1/50000 dilution
        Predicted band size: 86 kDa
        Observed band size: 100 kDa
    • 其他:

    產品詳情

    • 產品描述:

      MME, also called CD10, is a cell surface zinc metalloendopeptidase expressed in various normal and neoplastic lymphoid and nonlymphoid tissues including melanomas. It was previously used as a cell surface marker to identify and differentiate between hematological malignancies. CD10 expression varies in distinct cancer types. CD10 is highly expressed in prostate cancer, melanomas, and papillary thyroid cancer, while its expression is declined in cervical carcinoma and adenocarcinoma of the gastrointestinal tract.

      Compared with the polyclonal and monoclonal antibodies of MME, this MME recombinant antibody has the features of increased reproducibility and control, animal-free technology, high degree of monovalency, high batch-to-batch consistency, easier isotype conversion, etc. And it has been validated in ELISA, WB.

    • Uniprot No.:
    • 基因名:
      MME
    • 別名:
      Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10), MME, EPN
    • 反應種屬:
      Human
    • 免疫原:
      A synthesized peptide derived from human CD10
    • 免疫原種屬:
      Homo sapiens (Human)
    • 標記方式:
      Non-conjugated
    • 克隆類型:
      Monoclonal
    • 抗體亞型:
      Rabbit IgG
    • 純化方式:
      Affinity-chromatography
    • 克隆號:
      7F6
    • 濃度:
      It differs from different batches. Please contact us to confirm it.
    • 保存緩沖液:
      Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
    • 產品提供形式:
      Liquid
    • 應用范圍:
      ELISA, WB
    • 推薦稀釋比:
      Application Recommended Dilution
      WB 1:500-1:5000
    • Protocols:
    • 儲存條件:
      Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
    • 貨期:
      Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

    產品評價

    靶點詳情

    • 功能:
      Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.
    • 基因功能參考文獻:
      1. showed CD10 positivity in fibroblast-like stromal cells and fibrous material PMID: 29791034
      2. these data indicated under cigarette smoke condensate treatment; losing of membrane p120ctn could upregulate surface NEP protein level and thus facilitate BEAS-2B cell migration. PMID: 30249887
      3. High expression of CD10 is associated with lymph node invasion in colorectal cancer. PMID: 29653092
      4. We observed an increase of VCAM-1 urine levels in diabetic nephropathy-basal patients compared to diabetic controls and an increase of urinary neprilysin in DN-treated patients with persistent albuminuria PMID: 29854824
      5. Degradation of tropoelastin and skin elastin by neprilysin PMID: 29196110
      6. Xanthorrhizol (Xan) reduced 4-hydroxynonenal (HNE) levels on NEP proteins and preserved enzymatic activities of neprilysin (NEP) in HNE- or oligomeric Abeta42-treated cells. Xan reduced Abeta42 accumulation and protected neurones against oligomeric Abeta42-induced neurotoxicity through preservation of NEP activities PMID: 29330223
      7. These findings support the role of the stromal CD10 expression in breast cancer progression and dissemination, and suggest a relationship with cancer stem cells. PMID: 29306324
      8. Aberrant CD10 and BCL6 expression defines a subset of MCLs with higher mean Ki-67 index and higher prevalence of MUM1 expression PMID: 28628241
      9. Our study firstly confirmed the association of MME miRNA binding site polymorphism with the risk of LOAD. However, the association results warrant further validation. PMID: 28294061
      10. the Ras signaling pathway is involved in HIV-1 Tat-induced changes in ZO-1 and NEP. PMID: 28553432
      11. In this meta-analysis of the Han Chinese population, neprilysin confers genetic susceptibility to Alzheimer's disease in Han Chinese populations. PMID: 26362309
      12. High CD10 expression is associated with lymphoma in Waldeyer ring. PMID: 27616053
      13. Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies PMID: 27588448
      14. CD10 down expression in follicular lymphoma correlates with gastrointestinal lesion involving the stomach and large intestine PMID: 27513891
      15. High CD10 expression is associated with Basal cell carcinoma of the skin. PMID: 27039776
      16. the dynamic behavior of human NEP and NEP2 proteins was monitored by conducting molecular dynamics (MD) simulations. PMID: 26846903
      17. This study reveals some unusual findings in otherwise classical disease entity, like absence of palpable spleen, presence of lymphadenopathy, normal or elevated leukocyte counts, expression of CD10, which at times could be diagnostically challenging. PMID: 26609034
      18. Case Report: endometrial mixed carcinoma with the neuroendocrine component expressing CD10 that showed a long survival. PMID: 26830028
      19. CD10 and Bcl2 expression in tumor cells could give convincing diagnostic value to distinguish squamous cell carcinoma from seborrheic keratosis PMID: 26573127
      20. The peptide qf-Abeta(12-18)C (sequence VHHQKLVC) was cleaved by multiple Abeta-degrading enzymes, including NEP, ACE, and ECE-1, whereas the redesigned peptide qf-Abeta(12-16)AAC (sequence VHHQKAAC) was sensitive to NEP and ACE only. PMID: 27096746
      21. Loss-of-function MME mutations are the most frequent cause of adult-onset autosomal-recessive Charcot-Marie-Tooth disease type 2 in Japan. PMID: 26991897
      22. CD10 positivity is luminal/membranous in most benign apocrine breast lesions, the staining being nonuniversal and sometimes focal; analogous staining in apocrine malignancies seems rarer in DCIS and even rarer in invasive apocrine carcinomas, but atypical cytoplasmic positivity may also occur PMID: 26562027
      23. These findings indicate that CD10 may promote tumor progression by regulating the expression profiles of genes related to cell proliferation, angiogenesis, and resistance to apoptosis. PMID: 26881775
      24. CD10 gene expression plays a role in the pathogenesis of diffuse large B-cell lymphoma. PMID: 26414904
      25. High tumoral CD10 expression correlates with aggressive histology in patients with malignant pleural mesothelioma. PMID: 25608772
      26. In stage I lung adenocarcinoma, tumoral CD10 correlated with high-grade histology and was an independent predictor of recurrence in intermediate-grade tumors. PMID: 26141216
      27. CD10 strongly labelled only the gastrointestinal cells, with a well-defined apical membrane signal PMID: 24754336
      28. High CD10 expression is associated with Phylloides Tumors. PMID: 25921112
      29. The expression of neprilysin is increased in glioma cells following 5-HT2C activation. PMID: 25452160
      30. CD10 expression is related to a distinct gene expression signature in mantle cell lymphoma cases, but is without clinical or biological implications. PMID: 26124315
      31. Correlation between CD10 stromal expression and disease-free survival rate in breast cancer patients. PMID: 23575921
      32. E-cadherin and CD10 in endometrial lesions is not correlated, but reduced expression of both molecules could be critical for progression of endometrial carcinoma PMID: 25282623
      33. Evaulate CD10 and mucin expression in relation to microsatellite instability/mismatch repair proteins in 47 cases of small bowel adenocarcinoma. PMID: 25759539
      34. This meta-analysis indicates that rs3736187 (A/G) polymorphisms may be a potential beneficial single nucleotide polymorphism (SNP), which are associated with a decreased risk in Alzheimer disease. PMID: 25125048
      35. Follicular lymphoma CD10(pos) follicular helper T cells specifically display an IL-4(hi)IFN-gamma(lo) cytokine profile and encompass the malignant B-cell-supportive follicular helper T cells subset. PMID: 25733581
      36. Letter: suggest that CD10 is not a useful marker to differentiate seminoma from non-seminomatous germ cell tumours. PMID: 25713420
      37. This study gives substantial proof to the various models/research papers explaining the role of CD10 in breast cancer pathogenesis. PMID: 25308002
      38. Immunohistochemical distinction of renal cell carcinoma from other carcinomas with clear-cell histomorphology: utility of CD10 and CA-125 in addition to PAX-2, PAX-8, RCCma, and adipophilin. PMID: 25279712
      39. Serum CD10 levels might serve as a useful marker of synchronous and metachronous liver metastasis in colorectal cancer. PMID: 24972738
      40. PKCepsilon activation may have therapeutic efficacy for AD by reducing neurotoxic Abeta accumulation as well as having direct anti-apoptotic and synaptogenic effects PMID: 24848988
      41. High CD10 expression is associated with squamous cell carcinoma. PMID: 24895167
      42. MME expression level was differentially altered in Crohn disease and ulcerative colitis patients. PMID: 23827863
      43. the recombinant brain-targeted neprilysin, ASN12, may be an effective treatment for AD and warrant further investigation in clinical trials. PMID: 24825898
      44. Expression of CD10 is associated with therapeutic resistance and cancer stem cell-like properties of head and neck squamous cell carcinoma. PMID: 24874475
      45. A direct up-regulation of stroma fibroblast MME expression under hypoxia might contribute to enhanced aggressiveness of hypoxic cancers. PMID: 24460801
      46. Data indicate an important, previously neglected, role of NEP for regulation of luminal factors in the epididymis and suggest a novel role for CNP/guanylyl cyclase B in the epididymal epithelium. PMID: 24099862
      47. only seminomas and intratubular germ cell neoplasia, the precursors of germ cell tumours, express CD10 PMID: 23857215
      48. study suggests that the severity of periodontal disease may be associated with the expression of metalloendopeptidase genes, including NEP, ECE1 and ADAM17, in the buccal mucosal epithelium. PMID: 23360525
      49. CD10 might be involved in the development of endometriosis due to its influence on CD44-dependent cell adhesion. PMID: 23653392
      50. Overexpression of membrane metalloendopeptidase inhibits substance P stimulation of cholangiocarcinoma growth. PMID: 24603459

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    • 相關疾?。?/div>
      Charcot-Marie-Tooth disease 2T (CMT2T); Spinocerebellar ataxia 43 (SCA43)
    • 亞細胞定位:
      Cell membrane; Single-pass type II membrane protein.
    • 蛋白家族:
      Peptidase M13 family
    • 數據庫鏈接:

      HGNC: 7154

      OMIM: 120520

      KEGG: hsa:4311

      STRING: 9606.ENSP00000353679

      UniGene: Hs.307734



    1v1周青梅郑宣木天寥
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