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  • Your Good Partner in Biology Research

    SLC25A6 Antibody, HRP conjugated

    Datasheet
    • 货号:
      CSB-PA021520LB01HU
    • 规格:
      ¥1320
    • 其他:

    产品详情

    • 产品名称:
      Rabbit anti-Homo sapiens (Human) SLC25A6 Polyclonal antibody
    • Uniprot No.:
    • 基因名:
      SLC25A6
    • 别名:
      SLC25A6; AAC3; ANT3; CDABP0051; ADP/ATP translocase 3; ADP,ATP carrier protein 3; ADP,ATP carrier protein, isoform T2; ANT 2; Adenine nucleotide translocator 3; ANT 3; Solute carrier family 25 member 6
    • 宿主:
      Rabbit
    • 反应种属:
      Human
    • 免疫原:
      Recombinant Human ADP/ATP translocase 3 protein (144-175AA)
    • 免疫原种属:
      Homo sapiens (Human)
    • 标记方式:
      HRP
    • 克隆类型:
      Polyclonal
    • 抗体亚型:
      IgG
    • 纯化方式:
      >95%, Protein G purified
    • 浓度:
      It differs from different batches. Please contact us to confirm it.
    • 保存缓冲液:
      Preservative: 0.03% Proclin 300
      Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
    • 产品提供形式:
      Liquid
    • 应用范围:
      ELISA
    • Protocols:
    • 储存条件:
      Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
    • 货期:
      Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

    产品评价

    靶点详情

    • 功能:
      ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it.
    • 基因功能参考文献:
      1. Human ANT3 expression is directly downregulated by overexpression of hcmv-miR-UL36-5p. PMID: 26212361
      2. The dynamics of the molecular interactions between the C-terminal region of PB1-F2 protein and VDAC1 and ANT3 were expounded by employing an in silico approach. PMID: 19669810
      3. Of three ANT isoforms expressed in yeast, ANC3 is the most efficient to restore yeast growth on a nonfermentable carbon source of a yeast mutant strain lacking its three endogenous ANC. PMID: 12450408
      4. Results demonstrate that induction of adenine nucleotide translocase 3 by interleukin-4 and interferon-gamma proceeds via pathways involving STAT6 and STAT1, respectively. PMID: 14746803
      5. ANT3 overexpression induces apoptosis in cultured cells. PMID: 15063741
      6. ANT3 has a potential role in T-helper cell survival and immune cell homeostasis. PMID: 16930576
      7. involvement of ANT in cell death is cell type- and stimulus-dependent PMID: 17855512
      8. These data suggest that the down-regulation of ANT3 levels upon stimulation with CPT may be involved in the molecular mechanism underlying acquired resistance to camptothecin. PMID: 19111545

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    • 亚细胞定位:
      Mitochondrion inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
    • 蛋白家族:
      Mitochondrial carrier (TC 2.A.29) family
    • 组织特异性:
      Expressed in erythrocytes (at protein level).
    • 数据库链接:

      HGNC: 10992

      OMIM: 300151

      KEGG: hsa:293

      STRING: 9606.ENSP00000370808

      UniGene: Hs.350927



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