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  • Your Good Partner in Biology Research

    MATK Antibody

    Datasheet
    • 货号:
      CSB-PA013519ESR1HU
    • 规格:
      ¥1320
    • 图片:
      • Western blot
        All lanes: MATK antibody at 5.06µg/ml
        Lane 1: MCF-7 whole cell lysate
        Lane 2: Hela whole cell lysate
        Secondary
        Goat polyclonal to rabbit IgG at 1/10000 dilution
        Predicted band size: 57, 52 kDa
        Observed band size: 52 kDa
      • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA013519ESR1HU at dilution of 1:100
      • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA013519ESR1HU at dilution of 1:100
    • 其他:

    产品详情

    • 产品名称:
      Rabbit anti-Homo sapiens (Human) MATK Polyclonal antibody
    • Uniprot No.:
    • 基因名:
      MATK
    • 别名:
      CHK antibody; Csk homologous kinase antibody; Csk type protein tyrosine kinase antibody; CTK antibody; DKFZp434N1212 antibody; EC 2.7.10.2 antibody; Hematopoietic consensus tyrosine lacking kinase antibody; Hematopoietic consensus tyrosine-lacking kinase antibody; HHYLTK antibody; Hydroxyaryl protein kinase antibody; HYL antibody; HYL tyrosine kinase antibody; HYLTK antibody; Leukocyte carboxyl terminal src kinase related antibody; Lsk antibody; matK antibody; MATK_HUMAN antibody; Megakaryocyte associated tyrosine kinase antibody; Megakaryocyte associated tyrosine protein kinase antibody; Megakaryocyte-associated tyrosine-protein kinase antibody; MGC1708 antibody; MGC2101 antibody; Protein kinase HYL antibody; Tyrosine kinase MATK antibody; Tyrosine protein kinase CTK antibody; Tyrosine-protein kinase CTK antibody; Tyrosylprotein kinase antibody
    • 宿主:
      Rabbit
    • 反应种属:
      Human
    • 免疫原:
      Recombinant Human Megakaryocyte-associated tyrosine-protein kinase protein (393-507AA)
    • 免疫原种属:
      Homo sapiens (Human)
    • 标记方式:
      Non-conjugated
    • 克隆类型:
      Polyclonal
    • 抗体亚型:
      IgG
    • 纯化方式:
      Antigen Affinity Purified
    • 浓度:
      It differs from different batches. Please contact us to confirm it.
    • 保存缓冲液:
      PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
    • 产品提供形式:
      Liquid
    • 应用范围:
      ELISA, WB, IHC
    • 推荐稀释比:
      Application Recommended Dilution
      WB 1:1000-1:5000
      IHC 1:20-1:200
    • Protocols:
    • 储存条件:
      Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
    • 货期:
      Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

    产品评价

    靶点详情

    • 功能:
      Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
    • 基因功能参考文献:
      1. After IGF-I stimulation, CTK is recruited to IGF-IR and its recruitment facilitates CTK's subsequent association with phospho-SHPS-1. PMID: 21799000
      2. ERBB2 binds to the SH2 domain of CHK and inhibits cell growth in human breast tumor cell lines PMID: 12122014
      3. Overexpression of the Csk homologous kinase facilitates phosphorylation of akt/protein kinase b in breast neoplasms PMID: 12429987
      4. CHK Leu223 stabilizes the movement of the alphaC-helix of the protein tyrosine kinase PMID: 12782282
      5. Loss of CHK expression is associated with human brain tumors PMID: 15329911
      6. Nuclear multi-lobulation in late S phase, which is dependent on polymerization and depolymerization of microtubules, may be involved in nuclear Chk-induced inhibition of proliferation. PMID: 15748901
      7. striking functional differences between the Csk and Chk SH2 domains and revealed functional similarities between the Chk and Src SH2 domains PMID: 15890649
      8. This study describes for the first time the Src-independent actions of CHK and provides novel insights into CHK function in neural cells. PMID: 16168623
      9. Matk/CHK is not functionally redundant with Csk, and this tyrosine kinase plays an important role as a regulator of immunologic responses PMID: 16574955
      10. Findings indicate that the importance of the N-terminal domain to Chk-induced tyrosine phosphorylation in the nucleus, and implicate that nuclear tyrosine-phosphorylated proteins may contribute to inhibition of cell proliferation. PMID: 16707123
      11. Progesterone increases MATK in mast cells and reducs cell proliferation. PMID: 17492661
      12. These results reveal a potentially important role for CHK in Src activation and tumorigenicity in colon cancer cells. PMID: 17934522
      13. CHK is capable of inhibiting the CXCL12-CXCR4 pathway in neuroblastoma. PMID: 18292939

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    • 亚细胞定位:
      Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.
    • 蛋白家族:
      Protein kinase superfamily, Tyr protein kinase family, CSK subfamily
    • 组织特异性:
      Expressed in various myeloid cell lines, detected in brain and lung.
    • 数据库链接:

      HGNC: 6906

      OMIM: 600038

      KEGG: hsa:4145

      STRING: 9606.ENSP00000378485

      UniGene: Hs.631845



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