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  • Your Good Partner in Biology Research

    KLRK1 Antibody

    Datasheet
    • 货号:
      CSB-PA012474LA01HU
    • 规格:
      ¥1320
    • 图片:
      • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA012474LA01HU at dilution of 1:100
      • Immunofluorescent analysis of A549 cells using CSB-PA012474LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
      • Western Blot
        Positive WB detected in: A549 whole cell lysate, HepG2 whole cell lysate
        All lanes: KLRK1 antibody at 3.7µg/ml
        Secondary
        Goat polyclonal to rabbit IgG at 1/50000 dilution
        Predicted band size: 26 kDa
        Observed band size: 34 kDa
    • 其他:

    产品详情

    • 产品名称:
      Rabbit anti-Homo sapiens (Human) KLRK1 Polyclonal antibody
    • Uniprot No.:
    • 基因名:
      KLRK1
    • 别名:
      KLRK1; D12S2489E; NKG2D; NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; CD antigen CD314
    • 宿主:
      Rabbit
    • 反应种属:
      Human
    • 免疫原:
      Recombinant Human NKG2-D type II integral membrane protein (73-216AA)
    • 免疫原种属:
      Homo sapiens (Human)
    • 标记方式:
      Non-conjugated

      本页面中的产品,KLRK1 Antibody (CSB-PA012474LA01HU),的标记方式是Non-conjugated。对于KLRK1 Antibody,我们还提供其他标记。见下表:

      可提供标记
      标记方式 货号 产品名称 应用
      HRP CSB-PA012474LB01HU KLRK1 Antibody, HRP conjugated ELISA
      FITC CSB-PA012474LC01HU KLRK1 Antibody, FITC conjugated
      Biotin CSB-PA012474LD01HU KLRK1 Antibody, Biotin conjugated ELISA
    • 克隆类型:
      Polyclonal
    • 抗体亚型:
      IgG
    • 纯化方式:
      >95%, Protein G purified
    • 浓度:
      It differs from different batches. Please contact us to confirm it.
    • 保存缓冲液:
      Preservative: 0.03% Proclin 300
      Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
    • 产品提供形式:
      Liquid
    • 应用范围:
      ELISA, WB, IHC, IF
    • 推荐稀释比:
      Application Recommended Dilution
      WB 1:500-1:5000
      IHC 1:20-1:200
      IF 1:50-1:200
    • Protocols:
    • 储存条件:
      Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
    • 货期:
      Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

    产品评价

    靶点详情

    • 功能:
      Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
    • 亚细胞定位:
      Cell membrane; Single-pass type II membrane protein. Note=Colocalized with HCST on the cell surface.
    • 组织特异性:
      Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs).
    • 数据库链接:

      HGNC: 18788

      OMIM: 611817

      KEGG: hsa:100528032

      STRING: 9606.ENSP00000240618

      UniGene: Hs.387787



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