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  • Your Good Partner in Biology Research

    CNDP1 Antibody

    Datasheet
    • 货号:
      CSB-PA439589
    • 规格:
      ¥1980
    • 图片:
      • The image is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA439589(CNDP1 Antibody) at dilution 1/30. (Original magnification: ×200)
      • The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA439589(CNDP1 Antibody) at dilution 1/30. (Original magnification: ×200)
      • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: CSB-PA439589(CNDP1 Antibody) at dilution 1/320, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
    • 其他:

    产品详情

    • Uniprot No.:
    • 基因名:
      CNDP1
    • 别名:
      Beta Ala His dipeptidase antibody; Beta-Ala-His dipeptidase antibody; Carnosinase 1 antibody; Carnosinase1 antibody; Carnosine dipeptidase 1 (metallopeptidase M20 family) antibody; Carnosine dipeptidase 1 antibody; CN1 antibody; CNDP 1 antibody; CNDP dipeptidase 1 antibody; Cndp1 antibody; CNDP1_HUMAN antibody; CPGL2 antibody; Glutamate carboxypeptidase like protein 2 antibody; Glutamate carboxypeptidase-like protein 2 antibody; HsT2308 antibody; MGC102737 antibody; MGC10825 antibody; MGC142072 antibody; OTTHUMP00000163751 antibody; Serum carnosinase antibody; UNQ1915/PRO4380 antibody
    • 宿主:
      Rabbit
    • 反应种属:
      Human,Mouse,Rat
    • 免疫原:
      Fusion protein of Human CNDP1
    • 免疫原种属:
      Homo sapiens (Human)
    • 标记方式:
      Non-conjugated
    • 抗体亚型:
      IgG
    • 纯化方式:
      Antigen affinity purification
    • 浓度:
      It differs from different batches. Please contact us to confirm it.
    • 保存缓冲液:
      -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
    • 产品提供形式:
      Liquid
    • 应用范围:
      ELISA,WB,IHC
    • 推荐稀释比:
      Application Recommended Dilution
      ELISA 1:2000-1:5000
      WB 1:500-1:2000
      IHC 1:50-1:200
    • Protocols:
    • 储存条件:
      Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
    • 货期:
      Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

    产品评价

    靶点详情

    • 功能:
      Catalyzes the peptide bond hydrolysis in Xaa-His dipeptides, displaying the highest activity toward carnosine (beta-alanyl-L-histidine) and anserine (beta-alanyl-3-methyl-histidine).
    • 基因功能参考文献:
      1. The distribution of the (CTG)5 homozygous genotype in the no-diabetic nephropathy (DN) and clinical-DN patients was comparable, a lower frequency was found in the biopsy proven-DN patients, particularly in females. We observed a significant trend towards high frequencies of the (CTG)5 homozygous genotype with increased time on dialysis. PMID: 28553654
      2. Considering that approximately 40 per cent of the population are homozygous for the 5L allele of (CTG) n repeat polymorphism in CNDP1 gene and seem to be less prone to develop DN, it is needed to evaluate whether the majority of diabetic patients (who do not have the 5L-5L genotype) would be benefited from supplementation with carnosine or with a more intensive monitoring PMID: 27834319
      3. Compared to healthy individuals and those with diabetes but no kidney disease, patients with diabetic nephropathy exhibited lower frequencies of 5L-5L genotype and 5L allele of CNDP1 gene, suggesting that this allele might confer protection against development of kidney disease in this population. PMID: 27834323
      4. genetic association studies in pediatric population in Germany: Data suggest that, in pediatric patients with chronic kidney disease, the nephroprotective effect of CNDP1 Mannheim genetic variant against disease progression is not restricted to patients with diabetic nephropathy. PMID: 27278783
      5. The experimentally measured higher affinity of homocarnosine for the enzyme relative to l-carnosine might be explained, at least in part, by more extensive interactions inside the monomeric and dimeric hCN1's active site. PMID: 27105448
      6. Data shows that higher carnosine content in human skeletal muscle is positively associated with insulin resistance and fasting metabolic preference for glucose. PMID: 26439389
      7. In gastrointestinal cancer, reduced plasma levels of CNDP1 associate with signs of catabolism and poor outcome. PMID: 25898255
      8. Alterations of serum carnosinase (CN1) activity has been associated with several pathological conditions, such as neurological disorders, chronic diseases and cancer PMID: 24566305
      9. This meta-analysis confirms that the carnosinase D18S880 microsatellite polymorphism is associated with daibetic nephropathy susceptibility, especially in the type 2 DM and the Caucasian population. PMID: 23402577
      10. Rs12604675-A in CNDP1 may confer susceptibility to overt proteinuria in Japanese women with type 2 diabetes. PMID: 23342076
      11. In this review, correlations between serum carnosine and carnosinase activity and polymorphism in CNDP1 gene are analyzed. The role of CNDP1 gene polymorphism the development of diabetic nephropathy and non-diabetic chronic kidney disease is discussed. PMID: 22706107
      12. Plasma levels of FLT and S100A9 proteins are up-regulated and CNDP1 levels are down-regulated in patients with glioblastoma. PMID: 23029420
      13. These findings provide nominal evidence supporting a role between CNDP1 variants and diabetic kidney disease. PMID: 21393041
      14. neither CNDP1 genotype nor the normal variation in circulating testosterone levels affects the muscular carnosine content PMID: 20865290
      15. Serum histidine dipeptide concentrations are not correlated to serum carnosinase activity PMID: 20971102
      16. CNDP1 polymorphism predicts progression to ESRD in patients with diabetic nephropathies, but only late after baseline measurements. PMID: 20711718
      17. CTG polymorphism of the CNDP1 gene does not affect survival of Chinese peritoneal dialysis subjects. PMID: 20979941
      18. Hyperglycemia enhances CNDP1 secretion and enzyme activity; data suggest that poor blood glucose control in diabetic patients might result in an increased enzyme secretion even in the presence of the (CTG)(5) allele. PMID: 20460427
      19. Association between the CNDP1 gene and diabetic nephropathy is sex specific and independent of susceptibility for type 2 diabetes. PMID: 20332346
      20. GCP II mRNA was detected in glial cells. Glial-rich regions, specifically the DLPFC and ERC white matter and the molecular and polymorphic layers in the hippocampus, express high levels of GCP II mRNA. PMID: 14560319
      21. diabetic patients with the carnosinase CNDP1 gene Mannheim variant are less susceptible for nephropathy PMID: 16046297
      22. no difference in allele or genotype frequency between centenarians & controls or between cardiovascular patients & controls; the recently identified functional carnosinase variant does not contribute to longevity or protect against coronary heart disease PMID: 16965804
      23. CPGL-B may be associated with cell growth and metastasis of HCC. PMID: 17121880
      24. This replicates the CNDP1 gene association with diabetic nephropathy (DN) that was initially detected in European Caucasians and in Arabs, and further demonstrates that the CNDP1 gene and carnosine pathway appear to play a role in susceptibility to DN. PMID: 17205963
      25. Diabetic patients homozygous for CNDP1 are protected against diabetic nephropathy. PMID: 17601991
      26. CN1-dependent susceptibility to diabetic nephropathy may at least in part be mediated by altered glucose metabolism in type 2 diabetic patients. PMID: 17601992
      27. South Asian Surinamese have a lower frequency of the 5/5 homozygous genotype, which was associated with lower carnosinase activity and genetic risk for developing diabetic nephropathy. PMID: 19577318

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    • 亚细胞定位:
      Secreted.
    • 蛋白家族:
      Peptidase M20A family
    • 组织特异性:
      Found in serum and adult nervous central system. Absent in serum from patients with homocarnosinosis.
    • 数据库链接:

      HGNC: 20675

      OMIM: 609064

      KEGG: hsa:84735

      STRING: 9606.ENSP00000351682

      UniGene: Hs.400613



    1v1周青梅郑宣木天寥
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