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  • Your Good Partner in Biology Research

    CHGB Antibody

    Datasheet
    • 貨號:
      CSB-PA005345LA01HU
    • 規格:
      ¥1320
    • 圖片:
      • Western Blot
        Positive WB detected in: Hela whole cell lysate, HEK293 whole cell lysate, NIH/3T3 whole cell lysate
        All lanes: CHGB antibody at 2.8μg/ml
        Secondary
        Goat polyclonal to rabbit IgG at 1/50000 dilution
        Predicted band size: 79 kDa
        Observed band size: 79 kDa
    • 其他:

    產品詳情

    • 產品名稱:
      Rabbit anti-Homo sapiens (Human) CHGB Polyclonal antibody
    • Uniprot No.:
    • 基因名:
      CHGB
    • 別名:
      CCB peptide antibody; Cg B antibody; CgB antibody; Chgb antibody; Chromogranin-B antibody; ChromograninB antibody; SCG1 antibody; SCG1_HUMAN antibody; Secretogranin 1 antibody; Secretogranin B antibody; Secretogranin I antibody; SgI antibody
    • 宿主:
      Rabbit
    • 反應種屬:
      Human, Mouse
    • 免疫原:
      Recombinant Human Secretogranin-1 protein (328-677AA)
    • 免疫原種屬:
      Homo sapiens (Human)
    • 標記方式:
      Non-conjugated

      本頁面中的產品,CHGB Antibody (CSB-PA005345LA01HU),的標記方式是Non-conjugated。對于CHGB Antibody,我們還提供其他標記。見下表:

      可提供標記
      標記方式 貨號 產品名稱 應用
      HRP CSB-PA005345LB01HU CHGB Antibody, HRP conjugated ELISA
      FITC CSB-PA005345LC01HU CHGB Antibody, FITC conjugated
      Biotin CSB-PA005345LD01HU CHGB Antibody, Biotin conjugated ELISA
    • 克隆類型:
      Polyclonal
    • 抗體亞型:
      IgG
    • 純化方式:
      >95%, Protein G purified
    • 濃度:
      It differs from different batches. Please contact us to confirm it.
    • 保存緩沖液:
      Preservative: 0.03% Proclin 300
      Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
    • 產品提供形式:
      Liquid
    • 應用范圍:
      ELISA, WB
    • 推薦稀釋比:
      Application Recommended Dilution
      WB 1:500-1:5000
    • Protocols:
    • 儲存條件:
      Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
    • 貨期:
      Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

    產品評價

    靶點詳情

    • 功能:
      Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
    • 基因功能參考文獻:
      1. evidence suggests that the P413L variant of chromogranin B is not associated with amyotrophic lateral sclerosis (ALS) risk or age at ALS onset (meta-analysis). PMID: 28795874
      2. Data suggest that chromogranin B (CGB) is a promising emerging biomarker in heart failure (HF) patients with unique potential to integrate information from myocardial stress and neuro-endocrine activation. PMID: 29098879
      3. Circulating chromogranin B (CgB) levels measured on Intensive Care Unit (ICU) admission provided additional prognostic information to established risk indices in acute respiratory failure (ARF) patients. PMID: 28049363
      4. results presented here suggest that CHGB variant alleles, the rare CHGB-L413 and common CHGB-P413, may act as modifiers of ALS disease dependent on their expression levels which is higher in females because of a sex-determining region Y element in the CHGB gene promoter. PMID: 28175304
      5. our results suggest that genetic variants of CHGB may have sex-specific effects on the risk of schizophrenia and provide useful preliminary information for further study. PMID: 28332369
      6. intracellular calcium binding protein Sg1 is increased in early multiple sclerosis (MS) patients compared to relapsing-remitting MS and neurological controls. PMID: 26152395
      7. The polymorphism P413L in the CHGB gene was not associated with sporadic amyotrophic lateral sclerosis in a group of Italian patients. PMID: 26003296
      8. A heterogeneous response to short- and long-term physical activities among circulating granin proteins, particularly chromogranin B. PMID: 23816467
      9. Results do not support the 413L variant of chromogranin B as a risk factor for sporadic amyotrophic lateral sclerosis in the French population. PMID: 20932227
      10. common polymorphism in the 3'-UTR (C+84A) of CHGB, which disrupts an A/U-rich messenger ribonucleic acid stability element, associates with not only CHGB secretion but also excretion of isoprostane PMID: 20888525
      11. The common CHGB promoter variants A-296C and A-261T, and their consequent haplotypes, alter binding of specific transcription factors to influence gene expression in cella as well as BP in vivo PMID: 20359597
      12. Genetic variation at the CHGB locus, in the proximal promoter, influences CHGB expression as well as catecholamine secretion and later the early heritable responses to environmental stress, and resting/basal Blood Pressure in the population. PMID: 20011129
      13. finding that CHGB may act as a susceptibility gene and modifier of onset in ALS is consistent with the emerging view that dysfunction of the secretory pathway may contribute to increased vulnerability of motor neurons PMID: 20007371
      14. Chromogranin B was selected as a candidate gene for schizophrenia. We systematically screened all the promoter and exon regions of the gene and detected 15 single nucleotide polymorphisms in a Chinese population. PMID: 11959426
      15. CgB may play some role in the early phase of neoplastic progression PMID: 12165659
      16. there are four different types of chromogranin B in pancreatic islets as demonstrated by region-specific antibodies PMID: 12438147
      17. 5 CgB fragments were measured in plasma: CgB1-16, CgB312-331, CgB439-451, CgB568-577, & CgB647-657. Substantial heritability, as measured by h2r, was observed for 3 of the fragment concentrations, CgB312-331, CgB439-451, and CgB568-577. PMID: 15138309
      18. 10 microsatellite markers were analyzed, and an association of schizophrenia was found with D20S882 and D20S905 that flank D20S95. The chromogranin B gene is 30 kb from D20S905. PMID: 15219467
      19. Overall, our results suggest that at least one locus in or close to the CHGB gene confers risk of the disorder and strengthen the evidence that CHGB is a promising susceptibility gene for schizophrenia in Chinese population. PMID: 17143778
      20. Locally infused tyramine produced dose-dependent pressor responses, predicted by family history of hypertension, sex, and genetic variants at loci, particularly CHGB, that encode the biosynthesis, storage, and metabolism of catecholamines. PMID: 18180394
      21. semiquantitative immunocytochemistry for chromogranin B in amyotrophic lateral sclerosis PMID: 18721831

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    • 亞細胞定位:
      Secreted. Note=Neuroendocrine and endocrine secretory granules.
    • 蛋白家族:
      Chromogranin/secretogranin protein family
    • 組織特異性:
      Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.
    • 數據庫鏈接:

      HGNC: 1930

      OMIM: 118920

      KEGG: hsa:1114

      STRING: 9606.ENSP00000368244

      UniGene: Hs.516874



    1v1周青梅郑宣木天寥
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