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  • Your Good Partner in Biology Research

    Apoa1 Antibody

    Datasheet
    • 货号:
      CSB-PA001913LA01RA
    • 规格:
      ¥1320
    • 图片:
      • Western Blot
        Positive WB detected in: Rat Heart tissue, Rat Liver tissue, Rat Spleen tissue, Rat Lung tissue, Rat Kidney tissue, Rat Brain tissue, Rat Stomach tissue
        All lanes: Apoa1 antibody at 1:2000
        Secondary
        Goat polyclonal to rabbit IgG at 1/50000 dilution
        Predicted band size: 31 kDa
        Observed band size: 31 kDa
    • 其他:

    产品详情

    • 产品名称:
      Rabbit anti-Rattus norvegicus (Rat) Apoa1 Polyclonal antibody
    • Uniprot No.:
    • 基因名:
      Apoa1
    • 别名:
      Apoa1Apolipoprotein A-I antibody; Apo-AI antibody; ApoA-I antibody; Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I antibody; ProapoA-I)] antibody
    • 宿主:
      Rabbit
    • 反应种属:
      Rat
    • 免疫原:
      Recombinant Rat Apoa1 protein (19-259AA)
    • 免疫原种属:
      Rattus norvegicus (Rat)
    • 标记方式:
      Non-conjugated

      本页面中的产品,Apoa1 Antibody (CSB-PA001913LA01RA),的标记方式是Non-conjugated。对于Apoa1 Antibody,我们还提供其他标记。见下表:

      可提供标记
      标记方式 货号 产品名称 应用
      HRP CSB-PA001913LB01RA Apoa1 Antibody, HRP conjugated ELISA
      FITC CSB-PA001913LC01RA Apoa1 Antibody, FITC conjugated
      Biotin CSB-PA001913LD01RA Apoa1 Antibody, Biotin conjugated ELISA
    • 克隆类型:
      Polyclonal
    • 抗体亚型:
      IgG
    • 纯化方式:
      >95%, Antigen Affinity purified & Affinity purified
    • 浓度:
      It differs from different batches. Please contact us to confirm it.
    • 保存缓冲液:
      Preservative: 0.03% Proclin 300
      Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
    • 产品提供形式:
      Liquid
    • 应用范围:
      ELISA, WB
    • 推荐稀释比:
      Application Recommended Dilution
      WB 1:1000-1:5000
    • Protocols:
    • 储存条件:
      Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
    • 货期:
      Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

    产品评价

    靶点详情

    • 功能:
      Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
    • 基因功能参考文献:
      1. both the route of administration and the formulation of apoA-I peptide significantly affect its pharmacokinetics and pharmacodynamics. PMID: 27881716
      2. ABCA1 is diminished and ABCG1 is increased by N-acetylcysteine, which counteracts the reduction in apo A-I-mediated cholesterol efflux PMID: 25305669
      3. Apolipoprotein A-I induces tubulin phosphorylation in association with cholesterol release in fetal rat astrocytes. PMID: 24814947
      4. ApoA-I may be a protective blood-borne factor involved in the remote ischemic preconditioning mechanism. PMID: 24155931
      5. It maintains cholesterol homeostasis. PMID: 24117066
      6. on neonatal rat ventricular cardiomyocytes, the aldosterone-dependent chronotropic effects of antiapoA-1 IgG involve the nongenomic activation of L-type calcium channels PMID: 22253414
      7. translocation of cholesterol and phospholipid into the cytosol is related to the apo A-I-mediated HDL assembly in astrocytes through functional association with caveolin-1 and a cyclosporin A-sensitive cyclophilin protein(s). PMID: 11773045
      8. ABCA1-dependent cholesterol mobilization to apoA-I increased new cholesterol synthesis, indicating depletion of the regulatory pool of hepatocyte cholesterol during HDL formation PMID: 14993246
      9. The association of CLPP with microtubules is mediated by caveolin-1, induced by apoA-I and regulates intracellular cholesterol trafficking for assembly of cellular lipids to apoA-I-HDL. PMID: 16606364
      10. Data show that a complex of apolipoprotein A-I and pregnenolone modulate the rate of protein biosynthesis in liver cells. PMID: 18457017
      11. ApoA-I reduced I/R-induced inflammatory responses, decreased renal microscopic damage and improved renal function. ApoA-I protects kidney from I/R injury by inhibiting inflammatory cytokines release and neutrophil infiltration and activation. PMID: 18535924

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    • 亚细胞定位:
      Secreted.
    • 蛋白家族:
      Apolipoprotein A1/A4/E family
    • 组织特异性:
      Major protein of plasma HDL, also found in chylomicrons.
    • 数据库链接:


    1v1周青梅郑宣木天寥
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