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  • Your Good Partner in Biology Research

    ATF6B Antibody

    Datasheet
    • 货号:
      CSB-PA275866
    • 规格:
      ¥2024
    • 图片:
      • Western blot analysis of extracts from COLO205 cells, using ATF6B antibody.
    • 其他:

    产品详情

    • Uniprot No.:
    • 宿主:
      Rabbit
    • 反应种属:
      Human
    • 免疫原:
      Synthesized peptide derived from internal of Human ATF6B.
    • 免疫原种属:
      Homo sapiens (Human)
    • 克隆类型:
      Polyclonal
    • 纯化方式:
      The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • 浓度:
      It differs from different batches. Please contact us to confirm it.
    • 产品提供形式:
      Liquid
    • 应用范围:
      ELISA,WB
    • 推荐稀释比:
      Application Recommended Dilution
      WB 1:500-1:3000
    • Protocols:
    • 储存条件:
      Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
    • 货期:
      Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

    产品评价

    靶点详情

    • 功能:
      Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane. Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR).; Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.
    • 基因功能参考文献:
      1. ATF4 and ATF6beta act synergistically in the negative regulation of placental growth factor mRNA expression PMID: 26648175
      2. unglycosylated ATF6beta may directly facilitate the expression of ERSR genes by losing its repressor function to ATF6alpha PMID: 19693772
    • 亚细胞定位:
      Endoplasmic reticulum membrane; Single-pass type II membrane protein.; [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Nucleus.
    • 蛋白家族:
      BZIP family, ATF subfamily
    • 组织特异性:
      Ubiquitous.
    • 数据库链接:

      HGNC: 2349

      OMIM: 600984

      KEGG: hsa:1388

      STRING: 9606.ENSP00000364349

      UniGene: Hs.42853



    1v1周青梅郑宣木天寥
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