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  • Your Good Partner in Biology Research

    ANGPT4 Antibody

    Datasheet
    • 货号:
      CSB-PA584378
    • 规格:
      ¥1980
    • 图片:
      • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA584378(ANGPT4 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)
      • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA584378(ANGPT4 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)
      • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human right lung tissue, Human left lung cancer tissue, Primary antibody: CSB-PA584378(ANGPT4 Antibody) at dilution 1/480, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
    • 其他:

    产品详情

    • Uniprot No.:
    • 基因名:
      ANGPT4
    • 别名:
      AGP4 antibody; ANG-3 antibody; ANG-4 antibody; ANG3 antibody; ANG4 antibody; Angiopoietin 3 antibody; Angiopoietin 4 antibody; Angiopoietin-3 antibody; Angiopoietin-4 antibody; ANGP4_HUMAN antibody; ANGPT4 antibody; dJ824F16.2 (angiopoietin 4) antibody; MGC138181 antibody; MGC138183 antibody; OTTHUMP00000029947 antibody
    • 宿主:
      Rabbit
    • 反应种属:
      Human
    • 免疫原:
      Synthetic peptide of Human ANGPT4
    • 免疫原种属:
      Homo sapiens (Human)
    • 标记方式:
      Non-conjugated
    • 抗体亚型:
      IgG
    • 纯化方式:
      Antigen affinity purification
    • 浓度:
      It differs from different batches. Please contact us to confirm it.
    • 保存缓冲液:
      -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
    • 产品提供形式:
      Liquid
    • 应用范围:
      ELISA,WB,IHC
    • 推荐稀释比:
      Application Recommended Dilution
      ELISA 1:2000-1:10000
      WB 1:200-1:1000
      IHC 1:100-1:300
    • Protocols:
    • 储存条件:
      Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
    • 货期:
      Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

    产品评价

    靶点详情

    • 功能:
      Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
    • 基因功能参考文献:
      1. Ang-4 also promoted survival of LECs. Thus, blocking Ang-4 may prune the draining lymphatic vasculature and decrease interstitial fluid pressure (IFP) by reducing vascular permeability. PMID: 25977256
      2. acute-phase protein A1AT is a physiological regulator of angptl4, another acute-phase protein. PMID: 24760148
      3. Angptl4 is a glucocorticoid-responsive mediator of fasting-induced intracellular lipolysis and stimulates cAMP signaling in adipocytes PMID: 22267746
      4. In tumor cells, only Ang-4 expression has prognostic impact in NSCLC. In NSCLC tumor stroma, Ang-4 and Ang-2 are independently associated with survival. PMID: 21603628
      5. Linkage to 20p13 including the ANGPT4 gene in families with mixed Alzheimer disease and vascular dementia is reported. PMID: 20596041
      6. Results establish the novel effects of Ang-4 on tumor angiogenesis and GBM progression and suggest that this pro-GBM effect of Ang-4 is mediated by promoting tumor angiogenesis and activating Erk1/2 kinase in GBM cells. PMID: 20823154
      7. the angiopoietin/Tie-2 system may participate in the angiogenic response to hypoxia in renal tissues and in tumor angiogenesis in renal carcinoma. PMID: 15198927
      8. Recombinant Ang4 formed disulfide-linked dimers. Ang4 produces corneal angiogenesis extending from the limbus across the mouse cornea in vivo. Ang4 is an agonist of Tie2. PMID: 15284220
      9. angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure PMID: 16790085
      10. Results describe the expression of angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumors, leiomyomas and schwannomas. PMID: 17724803

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    • 亚细胞定位:
      Secreted.
    • 组织特异性:
      Highly expressed in the lung with much lower levels found in other tissues.
    • 数据库链接:

      HGNC: 487

      OMIM: 603705

      KEGG: hsa:51378

      STRING: 9606.ENSP00000371347

      UniGene: Hs.278973



    1v1周青梅郑宣木天寥
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