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  • Your Good Partner in Biology Research

    ALDH1A2 Antibody

    Datasheet
    • 貨號:
      CSB-PA001566EA01HU
    • 規格:
      ¥1320
    • 圖片:
      • Western Blot
        Positive WB detected in: K562 whole cell lysate, Mouse kidney tissue
        All lanes: ALDH1A2 antibody at 3.5µg/ml
        Secondary
        Goat polyclonal to rabbit IgG at 1/50000 dilution
        Predicted band size: 57, 54, 55, 47 kDa
        Observed band size: 54 kDa
      • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA001566EA01HU at dilution of 1:100
      • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA001566EA01HU at dilution of 1:100
    • 其他:

    產品詳情

    • 產品名稱:
      Rabbit anti-Homo sapiens (Human) ALDH1A2 Polyclonal antibody
    • Uniprot No.:
    • 基因名:
      ALDH1A2
    • 別名:
      AL1A2_HUMAN antibody; Aldehyde dehydrogenase family 1 member A2 antibody; ALDH1A2 aldehyde dehydrogenase 1 family; member A2 antibody; ALDH1A2 antibody; Aldh1a7 antibody; AV116159 antibody; MGC26444 antibody; RALDH 2 antibody; RALDH(II) antibody; Raldh1 antibody; RalDH2 antibody; RALDH2 T antibody; Retinal dehydrogenase 2 antibody; Retinaldehyde dehydrogenase 2 antibody; Retinaldehyde specific dehydrogenase type 2 antibody; Retinaldehyde-specific dehydrogenase type 2 antibody
    • 宿主:
      Rabbit
    • 反應種屬:
      Human, Mouse
    • 免疫原:
      Recombinant Human Retinal dehydrogenase 2 protein (1-518AA)
    • 免疫原種屬:
      Homo sapiens (Human)
    • 標記方式:
      Non-conjugated

      本頁面中的產品,ALDH1A2 Antibody (CSB-PA001566EA01HU),的標記方式是Non-conjugated。對于ALDH1A2 Antibody,我們還提供其他標記。見下表:

      可提供標記
      標記方式 貨號 產品名稱 應用
      HRP CSB-PA001566EB01HU ALDH1A2 Antibody, HRP conjugated ELISA
      FITC CSB-PA001566EC01HU ALDH1A2 Antibody, FITC conjugated
      Biotin CSB-PA001566ED01HU ALDH1A2 Antibody, Biotin conjugated ELISA
    • 克隆類型:
      Polyclonal
    • 抗體亞型:
      IgG
    • 純化方式:
      >95%, Protein G purified
    • 濃度:
      It differs from different batches. Please contact us to confirm it.
    • 保存緩沖液:
      Preservative: 0.03% Proclin 300
      Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
    • 產品提供形式:
      Liquid
    • 應用范圍:
      ELISA, WB, IHC
    • 推薦稀釋比:
      Application Recommended Dilution
      WB 1:500-1:5000
      IHC 1:20-1:200
    • Protocols:
    • 儲存條件:
      Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
    • 貨期:
      Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

    產品評價

    靶點詳情

    • 功能:
      Converts retinaldehyde to retinoic acid. Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal. Displays complete lack of activity with citral.
    • 基因功能參考文獻:
      1. The authors findings indicate that the SNP rs4238326 in ALDH1A2 gene may potentially modify individual susceptibility to knee OA in the Chinese population. PMID: 28089900
      2. high transcription activities of ALDH1A2, ALDH1A3 and ALDH1L1 predicted worsen overall survival in gastric cancer patients PMID: 27015121
      3. Data show that hRALDH2 is not inhibited by its oxidation product, all-trans-RA, suggesting the absence of a negative feedback regulatory loop. Expression of the Raldh2 gene is known to be regulated by RA itself, suggesting that the main regulation of the hRALDH2 activity level is transcriptional. PMID: 27001866
      4. Study shows no evidence that genetic variants alter prostate cancer incidence, but show that SNPs in the ALDH1A2 gene affect prostate cancer mortality. PMID: 27643404
      5. a critical role of ALDH1A2-RAR signaling in the pathogenesis of head and neck cancer. PMID: 26634247
      6. High expression of ALDH1A2 and ALDH1B1 mRNA was found to be significantly correlated to worser survival in all NSCLC patients. PMID: 26366059
      7. the distribution of RALDH1, RALDH2, and RALDH3 in the postnatal eye was determined. PMID: 25793304
      8. ALDH1A2 is involved in the regulation of cancer stem cell properties in neuroblastoma. PMID: 25524880
      9. At the transcript level, the cisplatin + DEAB-resistant cells showed upregulated mRNA expression levels for ALDH1A2, ALDH1A3 isozymes and CD44 indicating the involvement of these markers in conferring chemoresistance PMID: 24884875
      10. DNA methylation at multiple CpG sites is associated with loss of control over alcohol drinking. PMID: 24236815
      11. Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31. PMID: 24728293
      12. These findings suggest that ALDH1A2 is the enzyme involved in retinoic acid biosynthesis in human germ cells. PMID: 24524833
      13. all three proteins (RDH10, RALDH2, and CRABP2) appeared to be required for ATRA production induced by activation of PPARgamma PMID: 23833249
      14. ALDH1A2 protein was effective in AraC resistance. ALDH1A2 knock-down induced sensitivity to AraC treatment in K562AC cells. ALDH1A2 overexpressed K562S cells acquired the AraC resistance. Ara-C-resistant patients had increased ALDH1A2. PMID: 23507523
      15. In vivo reduction of vitamin A levels results in an increase in astrocyte RALDH2 expression in the hippocampus. PMID: 22930583
      16. Aberrant methylation of ALDH1a2 gene is the main cause for gene transcriptional inactivation in human bladder cancer cell lines. 5-Aza-2'-deoxycitydine or trichostatin A treatment induces ALDH1a2 expression. PMID: 20450613
      17. A human ALDH1A2 gene variant is associated with increased newborn kidney size and serum retinoic acid. PMID: 20375987
      18. Individual variation in ALDH1A2/CRABP2 genes may account for subtle variations in retinoic acid-dependent human embryogenesis. PMID: 20308937
      19. The results of this study suggested a positive association between ALDH1A2 and schizophrenics in the Chinese population and support the retinoid hypothesis of schizophrenia. PMID: 19703508
      20. polymorphisms in ALDH1A2 may influence the risk for lumbosacral myelomeningocele PMID: 16237707
      21. Raldh2-/- knockout embryos exhibit defective morphogenesis of various forebrain derivatives, including the ventral diencephalon, the optic and telencephalic vesicles. PMID: 16368932
      22. Gene duplication event that gave rise to Aldh1a1 and Aldh1a2 was more recent than the duplication event that gave rise to Aldh1a3. PMID: 19478994
      23. our screen indicates that ALDH1A2 genetic variation is present in tetralogy of Fallot patients, suggesting a possible causal role for this gene in rare cases of human congenital heart disease PMID: 19886994

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    • 亞細胞定位:
      Cytoplasm.
    • 蛋白家族:
      Aldehyde dehydrogenase family
    • 數據庫鏈接:

      HGNC: 15472

      OMIM: 603687

      KEGG: hsa:8854

      STRING: 9606.ENSP00000249750

      UniGene: Hs.643455



    1v1周青梅郑宣木天寥
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