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  • Your Good Partner in Biology Research

    ACTN2 Antibody

    Datasheet
    • 货号:
      CSB-PA001242LA11HU
    • 规格:
      ¥1320
    • 图片:
      • Western Blot
        Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate, Rat Brain tissue
        All lanes: ACTN2 antibody at 1:2000
        Secondary
        Goat polyclonal to rabbit IgG at 1/50000 dilution
        Predicted band size: 104 kDa
        Observed band size: 104 kDa
      • IHC image of CSB-PA001242LA11HU diluted at 1:500 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • 其他:

    产品详情

    • 产品名称:
      Rabbit anti-Homo sapiens (Human) ACTN2 Polyclonal antibody
    • Uniprot No.:
    • 基因名:
      ACTN2
    • 别名:
      Actin binding protein antibody; Actinin alpha 2 antibody; ACTN 2 antibody; ACTN2 antibody; ACTN2_HUMAN antibody; Alpha actinin 2 antibody; Alpha actinin skeletal muscle antibody; Alpha actinin skeletal muscle isoform 2 antibody; Alpha-actinin skeletal muscle isoform 2 antibody; Alpha-actinin-2 antibody; CMD1AA antibody; F actin cross linking protein antibody; F-actin cross-linking protein antibody
    • 宿主:
      Rabbit
    • 反应种属:
      Human, Rat
    • 免疫原:
      Recombinant Human Alpha-actinin-2 protein (1-301AA)
    • 免疫原种属:
      Homo sapiens (Human)
    • 标记方式:
      Non-conjugated

      本页面中的产品,ACTN2 Antibody (CSB-PA001242LA11HU),的标记方式是Non-conjugated。对于ACTN2 Antibody,我们还提供其他标记。见下表:

      可提供标记
      标记方式 货号 产品名称 应用
      HRP CSB-PA001242LB11HU ACTN2 Antibody, HRP conjugated ELISA
      FITC CSB-PA001242LC11HU ACTN2 Antibody, FITC conjugated
      Biotin CSB-PA001242LD11HU ACTN2 Antibody, Biotin conjugated ELISA
    • 克隆类型:
      Polyclonal
    • 抗体亚型:
      IgG
    • 纯化方式:
      >95%, Protein G purified
    • 浓度:
      It differs from different batches. Please contact us to confirm it.
    • 保存缓冲液:
      Preservative: 0.03% Proclin 300
      Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
    • 产品提供形式:
      Liquid
    • 应用范围:
      ELISA, WB, IHC
    • 推荐稀释比:
      Application Recommended Dilution
      WB 1:1000-1:5000
      IHC 1:100-1:500
    • Protocols:
    • 储存条件:
      Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
    • 货期:
      Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

    产品评价

    靶点详情

    • 功能:
      F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
    • 基因功能参考文献:
      1. A dual-beam optical tweezers measured the mechanics of alpha-actinin 2 and rabbit titin interaction at the single-molecule level. Depending on the direction of force application, the unbinding forces can more than triple. Multiple alpha-actinin/Z-repeat interactions cooperate to ensure long-term stable titin anchoring, while allowing the individual components to exchange dynamically. PMID: 28096424
      2. These results provide new insights into the regulation of SK2 channel trafficking by the cytoskeletal proteins FLNA and alpha-actinin2, involving distinct recycling pathways PMID: 27779751
      3. the interaction between GNE and alpha-actinin 1 and alpha-actinin 2 occur at different sites in the alpha-actinin molecules and that for alpha-actinin 2 the interaction site is located at the C-terminus of the protein. PMID: 27023225
      4. The full length mEos2 tagged protein expressed in adult cardiomyocytes shows that both mutations additionally affect Z-disc localization and dynamic behaviour PMID: 27287556
      5. study strengthens the hypothesis that ACTN2 influences caries risk. PMID: 24810274
      6. The novel heterozygous missense sequence variant ACTN2 cosegregated with a complex cardiomyopathic trait, characterized by the interplay of midapical, nonobstructive HCM, early onset of AF and AV block, as well as regional LV noncompaction. PMID: 25173926
      7. Clinical evaluation of an Australian family revealed diverse cardiac pathologies in four affected members and genetic testing of the exome identified a pathogenic ACTN2 heterozygous variant (Ala119Thr) that co-segregated with disease. PMID: 25224718
      8. Study reports a complete high-resolution structure of the 200 kDa alpha-actinin-2 dimer from striated muscle and explore its functional implications on the biochemical and cellular level. PMID: 25433700
      9. This study generated the genomic sequences of K88-positive and F18-positive porcine enteroteoxigenic E. coli (ETEC) strains and examined the phylogenetic distribution of clinical porcine ETEC strains and their plasmid-associated genetic content. PMID: 22081385
      10. Findigs show that the F-actin-binding protein alpha-actinin-2 targets CaMKIIalpha to F-actin in cells by binding to the CaMKII regulatory domain. PMID: 22427672
      11. data provide functional evidence that the primary sequences of alpha-actinin-2 and alpha-actinin-3 evolved differences to optimize their functions PMID: 22253474
      12. This is the first genome-wide linkage analysis that shows mutations in ACTN2 cause HCM PMID: 20022194
      13. BPAG1-b was detectable in vitro and in vivo as a high molecular mass protein in striated and heart muscle cells, co-localizing with alpha-actinin-2 and partially with the cytolinker plectin as well as with the intermediate filament protein desmin. PMID: 19932097
      14. Spectrin-like repeats from dystrophin and alpha-actinin-2 are not functionally interchangeable. PMID: 12140183
      15. Association of Ca2+-activated K+ channel with alpha-actinin2 localizes channel to entry of external Ca(2+) source, which regulates channel function. PMID: 17110593
      16. actinin-2 participate in sequestering parafibromin in the cytoplasmic compartment. PMID: 18687124
      17. ACTN2 expression is affected by the content of alpha-actinin-3. PMID: 19150855
      18. demonstrate that proper membrane localization of a small-conductance Ca(2+)-activated K(+) channel (SK2 or K(Ca)2.2) is dependent on its interacting protein, alpha-actinin2, a major F-actin crosslinking protein. PMID: 19815520

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    • 相关疾病:
      Cardiomyopathy, familial hypertrophic 23, with or without left ventricular non-compaction (CMH23); Cardiomyopathy, dilated 1AA, with or without left ventricular non-compaction (CMD1AA)
    • 亚细胞定位:
      Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.
    • 蛋白家族:
      Alpha-actinin family
    • 组织特异性:
      Expressed in both skeletal and cardiac muscle.
    • 数据库链接:

      HGNC: 164

      OMIM: 102573

      KEGG: hsa:88

      STRING: 9606.ENSP00000355537

      UniGene: Hs.498178



    1v1周青梅郑宣木天寥
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