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    Rat macrophage inflammatory protein 2,MIP-2 ELISA kit

    • 中文名称:
      大鼠巨噬细胞炎性蛋白2(MIP-2)ELISA Kit
    • 货号:
    • 规格:
    • 价格:
    • 其他:


    • 产品描述:

      The rat MIP-2 ELISA Kit is intended to measure rat MIP-2 in serum, plasma, or tissue homogenates. This assay uses the bi-antibody sandwich technique and enzyme-substrate chromogenic reaction to quantify rat MIP-2 concentration. The intensity of the colored product is directly proportional to the concentration of MIP-2 present in the sample. This rat MIP-2 ELISA kit has high specificity and excellent sensitivity.

      MIP-2, also called CXCL2, is a peptide derived from monocytes/ macrophages that attracts and recruits neutrophils to inflamed sites through the p38 MAPK-dependent signaling pathway, by binding to CXCR1 and CXCR2. CXCL2-recruited and activated neutrophils can accelerate liver inflammation by releasing various inflammatory mediators. CXCL2 expression is increased during hepatic I/R injury. Some studies have demonstrated that CXCL2 is overexpressed in breast, colon, prostate, and bladder cancers. While CXCL2 is down-regulated in HCC cell lines, inhibiting hepatocellular carcinoma (HCC) cell proliferation in vitro.

    • 别名:
      Cxcl2 ELISA kit; Cinc3 ELISA kit; Mip-2 ELISA kit; Mip2 ELISA kit; Scyb2C-X-C motif chemokine 2 ELISA kit; Cytokine-induced neutrophil chemoattractant 3 ELISA kit; CINC-3 ELISA kit; Macrophage inflammatory protein 2 ELISA kit; MIP2 ELISA kit
    • 缩写:
    • Uniprot No.:
    • 种属:
      Rattus norvegicus (Rat)
    • 样本类型:
      serum, plasma, tissue homogenates
    • 检测范围:
      78 pg/mL-5000 pg/mL
    • 灵敏度:
      19.5 pg/mL
    • 反应时间:
    • 样本体积:
    • 检测波长:
      450 nm
    • 研究领域:
    • 测定原理:
    • 测定方法:
    • 说明书:
    • 数据处理:
    • 货期:
      3-5 working days




    • 功能:
      Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. Contributes to neutrophil activation during inflammation.
    • 基因功能参考文献:
      1. this study shows elevated expression of CINC-3 at the site of inflammation as well as their significant reflection in the circulation, thereby suggesting their frontline role in carrageenan-induced acute inflammation PMID: 27967265
      2. rutin is a potential protective agent in spinal cord injury enhancing the neurotrophic effect by inhibiting the expression of MIP-2 and activation of MMP-9, and downregulating the expression of p-Akt. PMID: 26502930
      3. The rat spiral ligament fibrocytes were found to release CXCL2 in response to nontypeable H. influenzae via activation of c-Jun, leading to the recruitment of polymorphonuclear cells to the cochlea. PMID: 22379036
      4. CsA has no significant effect on serum levels of MCP-1 and MIP-2 following renal transplantation in rats. PMID: 20034917
      5. Results identify FQHPSFI peptide may be used for the modulation of lipopolysaccharide-stimulated MIP-2 production in alveolar macrophagess. PMID: 20186460
      6. chemokine production by rat alveolar macrophages is inhibited by taurine chloramine PMID: 11716962
      7. Intratracheal LPS induced a significant increase in MIP-2 in bronchoalveolar lavage (BAL) fluid with no detectable MIP-2 in the plasma. PMID: 11837784
      8. demonstrated that the beta-glucan component of the Pneumocystis carinii cell wall is able to stimulate alveolar epithelial cells to produce MIP-2 PMID: 11906040
      9. role for the nitric oxide pathway in the overproduction of pro-inflammatory mediators IL-6 and MIP-2 during GBS-induced lung inflammation. PMID: 12661899
      10. junctional epithelium cells produced MIP-2 and CINC-2 in response to LPS stimulation, suggesting that MIP-2 and CINC-2 may be responsible for PMN migration toward the periodontal pathogen and may play an important role in the initiation of inflammation PMID: 15045510
      11. macrophage inflammatory protein 2 mediates platelet-activating factor-induced intestinal injury PMID: 15319184
      12. no significant differences were detected for MIP-2 levels in diabetic rats when compared with non-diabetic rats after hypoxia PMID: 16132691
      13. Following cecal ligation and puncture Cxcl2 production increases in the lung, setting the stage for neutrophil accumulation in lung during sepsis. PMID: 16818791
      14. MIP-2/CXCL2 and MCP-1/CCL2 are increased after injury, and neurons appear to be the source of this expression. Chemokine expression was selectively inhibited by dexamethasone. PMID: 19210118



    • 亚细胞定位:
    • 蛋白家族:
      Intercrine alpha (chemokine CxC) family
    • 组织特异性:
      At least expressed in the lung and trachea.
    • 数据库链接:

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