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  • Your Good Partner in Biology Research

    Human monocyte chemotactic protein 2,MCP-2 ELISA kit

    • 中文名称:
      人单核细胞趋化蛋白2(MCP-2/CCL8)ELISA Kit
    • 货号:
      CSB-E04656h
    • 规格:
      96T/48T
    • 价格:
      ¥3600/¥2500
    • 其他:

    产品详情

    • 产品描述:

      The product CSB-E04656h is a sandwich ELISA kit developed to measure concentrations of human MCP-2 in serum, plasma, or tissue homogenates. This assay uses the sandwich enzyme immunoassay technique in combination with the enzyme-substrate chromogenic reaction to quantify the analyte in the sample. The color develops positively to the amount of MCP-2 in samples. The color intensity is measured at 450 nm via a microplate reader.

      MCP-2, also called CCL8, is a pro-inflammatory chemokine expressed in inflamed tissues by resident and infiltrated monocyte/macrophages after paracrine stimulation from T-cells by IFNs and other proinflammatory cytokines. It can also be induced through innate mechanisms upon contact with viral, bacterial, and fungal agents. CCL8 is an agonist of CCR1, CCR2, and CCR5 and plays a pivotal role in the control of leukocyte chemotaxis, HIV entry, and other inflammatory diseases. CCL8 exerts different roles in different tumors. It contributes to the dissemination of breast cancer and promotes the migration and invasion of esophageal squamous cell carcinoma. Studies have also confirmed that CCL8 suppresses the growth of cervical carcinoma tumors and exhibits an anti-tumor metastatic effect in melanoma.

    • 别名:
      Ccl8 ELISA Kit; CCL8_HUMAN ELISA Kit; HC14 ELISA Kit; MCP-2 ELISA Kit; MCP-2(6-76) ELISA Kit; Monocyte chemoattractant protein 2 ELISA Kit; Monocyte chemotactic protein 2 ELISA Kit; SCYA10 ELISA Kit; SCYA8 ELISA Kit; Small-inducible cytokine A8 ELISA Kit
    • 缩写:
      CCL8
    • Uniprot No.:
    • 种属:
      Homo sapiens (Human)
    • 样本类型:
      serum, plasma, tissue homogenates
    • 检测范围:
      15.6 pg/ml - 1000 pg/ml
    • 灵敏度:
      3.9 pg/ml
    • 反应时间:
      1-5h
    • 样本体积:
      50-100ul
    • 检测波长:
      450 nm
    • 研究领域:
      Immunology
    • 测定原理:
      quantitative
    • 测定方法:
      Sandwich
    • 数据处理:
    • 货期:
      3-5 working days

    产品评价

    靶点详情

    • 功能:
      Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.
    • 基因功能参考文献:
      1. It was shown that MCP2 was able to activate the NF-kappaB signaling pathway inducing the epithelial-mesenchymal transition (EMT) and promoting the migration and invasion of ESCC cells in vitro. PMID: 29148603
      2. Transcriptome analysis identified several novel IPF-related genes. Among them, CCL8 is a candidate molecule for the differential diagnosis and prediction of survival. PMID: 28057004
      3. Findings exemplify how gradients of chemoattractive factors such as CCL8, drive metastasis and suggest that interference with their operation may provide means for breast cancer management. PMID: 27181207
      4. Detecting expression changes in TLR4 and MCP2 in the peripheral blood is a feasible method for predicting the occurrence of abortion in women of child-bearing age PMID: 27173235
      5. Dermal fibroblast CCL8 promotes melanoma metastasis. PMID: 26320180
      6. Authors show that the previously observed downregulation of hsa-miR-92a and upregulation of CCL8 during human cytomegalovirus latent infection of myeloid cells are intimately linked via the latency-associated expression of cytomegalovirus UL111A. PMID: 25253336
      7. CCL8 is an antimicrobial protein with bacteriocidal activity against E. coli. PMID: 12949249
      8. Results indicate that the induction of MCP-2/CCL8 by mycobacteria is dependent on the activation of TLR2/PI3K/Akt signaling pathway. PMID: 23418602
      9. Macrophage Colony Stimulating Factor and Monocyte Chemoattractant Protein are elevated in sera of intrinsic asthmatics compared to normal controls. PMID: 21945122
      10. genetic polymorphhism is associated with a risk of death for non-small cell lung cancer in Chinese PMID: 21514686
      11. Cytokine treatment increases mRNA stability only for chemokines CCL2 and CCL8 in airway epithelium, and transient silencing and overexpression of human antigen R affects only chemokine CCL2 and CCL8 expression in primary and transformed epithelial cells. PMID: 21220697
      12. CCL8/MCP-2 is a target for mir-146a in HIV-1 infected microglia, as overexpression of mir-146a prevented HIV-induced secretion of MCP-2 chemokine PMID: 20181935
      13. TRAIL pretreatment of endothelial cells down-modulated mRNA steady-state levels of several TNF-alpha-induced chemokines, and it abrogated the TNF-alpha-mediated up-regulation of CCL8 and CXCL10, modulating leukocyte/endothelial cell adhesion PMID: 15644410
      14. Angiotensin II directly stimulates MCP-2 expression through AT1-receptors in activated macrophages PMID: 17487826
      15. CCL8 is a promising specific serum marker for the early and accurate diagnosis of graft-versus-host disease. PMID: 18256320
      16. A new finding is the differential distribution of CCL8 marker alleles and a haplotype in extreme severity subgroups of MS. PMID: 18602166
      17. IP-10 and MCP-2 are expressed in tuberculosis patients PMID: 18684849
      18. 5-Amino-4-imidazole carboxamide riboside (AICAR) markedly increases UCP-2 expression and reduced both reactive oxygen species and prostacyclin synthase nitration. PMID: 18835932
      19. These data indicate that optimal induction and delivery of MCP-2/CCL8 is counteracted by converting this chemokine into a receptor antagonist, thereby losing its anti-tumoral potential. PMID: 19224633
      20. CCL8/MCP rs1133763 SNP, or other variants in linkage disequilibrium with this variant, likely do not influence the susceptibility to AD or FTLD in Caucasians. PMID: 19415413

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    • 亚细胞定位:
      Secreted.
    • 蛋白家族:
      Intercrine beta (chemokine CC) family
    • 组织特异性:
      Highest expression found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, spleen and prostate.
    • 数据库链接:

      HGNC: 10635

      OMIM: 602283

      KEGG: hsa:6355

      STRING: 9606.ENSP00000378118

      UniGene: Hs.271387



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