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    Human Complement component C6(C6) ELISA kit

    • 中文名称:
      Human Complement component C6(C6) ELISA kit
    • 货号:
      CSB-EL004036HU
    • 规格:
      96T/48T
    • 价格:
      ¥3600/¥2500
    • 其他:

    产品详情

    • 产品描述:

      This Human complement component 6 ELISA Kit was designed for the quantitative measurement of Human complement component 6 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 62.5 pg/mL-4000 pg/mL and the sensitivity is 15.6 pg/mL.

    • 别名:
      AW111623 ELISA Kit; C6 ELISA Kit; CO6_HUMAN ELISA Kit; Complement component 6 ELISA Kit; Complement component C6 ELISA Kit
    • 缩写:
      C6
    • Uniprot No.:
    • 种属:
      Homo sapiens (Human)
    • 样本类型:
      serum, plasma, tissue homogenates
    • 检测范围:
      62.5 pg/mL-4000 pg/mL
    • 灵敏度:
      15.6 pg/mL
    • 反应时间:
      1-5h
    • 样本体积:
      50-100ul
    • 检测波长:
      450 nm
    • 研究领域:
      Immunology
    • 测定原理:
      quantitative
    • 测定方法:
      Sandwich
    • 说明书:
    • 精密度:
      Intra-assay Precision (Precision within an assay): CV%<8%        
      Three samples of known concentration were tested twenty times on one plate to assess.    
      Inter-assay Precision (Precision between assays): CV%<10%        
      Three samples of known concentration were tested in twenty assays to assess.      
                     
    • 线性度:
      To assess the linearity of the assay, samples were spiked with high concentrations of human C6 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
        Sample Serum(n=4)    
      1:10000 Average % 88    
      Range % 81-92    
      1:20000 Average % 95    
      Range % 91-105    
      1:40000 Average % 97    
      Range % 92-101    
      1:80000 Average % 93    
      Range % 86-98    
    • 回收率:
      The recovery of human C6 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
       
      Sample Type Average % Recovery Range    
      Serum (n=5) 92 85-98    
      EDTA plasma (n=4) 95 90-100    
                     
                     
    • 标准曲线:
      These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
       
      pg/ml OD1 OD2 Average Corrected    
      4000 2.021 2.107 2.064 1.940    
      2000 1.745 1.784 1.765 1.641    
      1000 1.318 1.329 1.324 1.200    
      500 0.902 0.894 0.898 0.774    
      250 0.651 0.668 0.660 0.536    
      125 0.489 0.492 0.491 0.367    
      62.5 0.337 0.341 0.339 0.215    
      0 0.122 0.125 0.124      
    • 数据处理:
    • 货期:
      3-5 working days

    产品评价

    靶点详情

    • 功能:
      Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
    • 基因功能参考文献:
      1. Our study provided novel evidence that genetic variations in complement genes C6 and MASP1were associated with preeclampsia risk, and that the risk varied by preeclampsia subtypes PMID: 27405496
      2. recipient C6 rs9200 polymorphism is associated with HCC recurrence after OLT, and improves the predictive value of clinical models. PMID: 27173880
      3. Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC). PMID: 22267737
      4. finding of very high serious morbidity in patients with complete C6 deficiency due to meningococcal infections PMID: 22288589
      5. Genetic polymorphisms in C6 gene do not influence the risk of aspirin hypersensitivity in Korean asthmatic patients. PMID: 21704099
      6. produced by trophoblast cells PMID: 19665237
      7. The most common defect, which leads to an increased susceptibility to Neisseria meningitidis infections in the Western Cape, is 879delG. PMID: 17257682

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    • 相关疾病:
      Complement component 6 deficiency (C6D)
    • 亚细胞定位:
      Secreted.
    • 蛋白家族:
      Complement C6/C7/C8/C9 family
    • 数据库链接:

      HGNC: 1339

      OMIM: 217050

      KEGG: hsa:729

      STRING: 9606.ENSP00000263413

      UniGene: Hs.481992



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